Evidence map›Paper›PMID 27186584›Full record

ArticleOpen forum infectious diseases2016

Human Immunodeficiency Virus/Hepatitis C Virus Coinfection in Spain: Prevalence and Patient Characteristics.

Juan Berenguer, Antonio Rivero, Inmaculada Jarrín, María J Núñez, María J Vivancos, Manel Crespo, María J Téllez, Pere Domingo, José A Iribarren, Arturo Artero and 5 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Hepatitis B and C prevalence and incidence in key population groups with multiple risk factors in the EU/EEA: a systematic review.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019
    Pooled it
  2. Trial
  3. Trends in Hepatitis C Virus Infection Prevalence Among People With HIV in Spain Over 2 Decades (2002-2023).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  4. Article
  5. Plasmablastic Lymphoma. A State-of-the-Art Review: Part 2-Focus on Therapy.Mediterranean journal of hematology and infectious diseases · 2024
    Review
  6. Article
  7. Real-life experience of hepatitis C treatment in a Spanish prison.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022
    Observational
  8. Article
  9. Article
  10. [Hepatitis C: New diagnosis and seroconversions in a Madrid sexually transmitted diseases clinic].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2019
    Article
  11. Increasing importance of European lineages in seeding the hepatitis C virus subtype 1a epidemic in Spain.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019
    Article
  12. Article
  13. Observational
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Review
  20. Impact of universal access to hepatitis C therapy on HIV-infected patients: implementation of the Spanish national hepatitis C strategy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Juan BerenguerHospital General Universitario Gregorio Marañón; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid.
Antonio RiveroHospital Universitario Reina Sofia, Cordoba; Instituto Maimonides de Investigacion Biomedica de Cordoba.
Inmaculada JarrínCentro Nacional de Epidemiología, Instituto de Salud Carlos III.
María J NúñezHospital Universitario La Paz; Instituto de Investigación Sanitaria La Paz.
María J VivancosHospital Universitario Ramón y Cajal , Madrid.
Manel CrespoHospital Universitari Vall d'Hebron , Barcelona.
María J TéllezHospital Clínico San Carlos , Madrid.
Pere DomingoHospital de la Santa Creu i Sant Pau , Barcelona.
José A IribarrenHospital Donostia , San Sebastián.
Arturo ArteroHospital Universitario Doctor Peset , Valencia.
Manuel MárquezHospital Universitario Virgen de la Victoria , Málaga.
Ignacio SantosHospital Universitario de La Princesa , Madrid.
Javier MorenoHospital Universitario Miguel Servet , Zaragoza.
Marta MonteroHospital Universitario La Fe , Valencia , Spain.
Juan González-GarcíaHospital Universitario La Paz; Instituto de Investigación Sanitaria La Paz.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background.  The purpose of this study was to assess the prevalence of anti-hepatitis C virus (HCV) antibodies (Abs) and active HCV infection in human immunodeficiency virus (HIV)-infected (HIV+) patients in Spain in 2015. This was a cross-sectional study. Methods.  The study was performed in 41 centers in 2015. Sample size was estimated for an accuracy of 2%, the number of patients from each hospital was determined by proportional allocation, and patients were selected using simple random sampling. Results.  The reference population was 35 791 patients, and the sample size was 1867 patients. Hepatitis C virus serostatus was known in 1843 patients (98.7%). Hepatitis C virus-Abs were detected in 695 patients (37.7%), in whom the main route of HIV acquisition was injection drug use (75.4%). Of these 695 patients, 402 had HCV RNA, 170 had had a sustained viral response (SVR) after anti-HCV therapy, and 102 cleared HCV spontaneously. Hepatitis C virus-ribonucleic acid results were unknown in 21 cases. Genotype distribution (known in 367 patients) was 1a in 143 patients (39.0%), 4 in 90 (24.5%) patients, 1b in 69 (18.8%) patients, 3 in 57 (15.5%) patients, 2 in 5 (1.4%) patients, and mixed in 3 (0.8%) patients. Liver cirrhosis was present in 93 patients (23.1%) with active HCV infection and in 39 (22.9%) patients with SVR after anti-HCV therapy. Conclusions.  The prevalence of HCV-Abs and active HCV infection in HIV+ patients in Spain is 37.7% and 22.1%, respectively; these figures are significantly lower than those recorded in 2002 and 2009. The predominant genotypes in patients with active HCV infection were 1a and 4. A high percentage of patients had cirrhosis. Cirrhosis is also common in patients with SVR after anti-HCV therapy.

Indexed as

coinfection/epidemiologyhepatitis C/drug therapy/epidemiologyHIV infections/epidemiologySpain/epidemiology

Identifiers

PMID27186584
PMCPMC4866570

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.