ArticleIndian journal of endocrinology and metabolism
Effect of maternal and neonatal factors on cord blood thyroid stimulating hormone.
Article in Indian journal of endocrinology and metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 32 citations in OpenAlex.
- Association of Certain Maternal and Neonatal Factors with Neonatal Thyroid-Stimulating Hormone Levels: Insights for Congenital Hypothyroidism Prevention.International journal of preventive medicine · 2026Article
- Impact of Maternal and Neonatal Factors on Thyroid-Stimulating Hormone Concentrations in Newborns in Eastern Morocco.Cureus · 2025Article
- Screening for congenital hypothyroidism by using cord blood thyroid stimulating hormone (CBTSH) levels in neonates.Journal of family medicine and primary care · 2025Article
- Association of pregnancy outcomes with neonatal TSH levels in euthyroid singleton pregnancies.Frontiers in endocrinology · 2025Observational
- Article
- Congenital hypothyroidism in India: A systematic review and meta-analysis of prevalence, screen positivity rates, and etiology.The Lancet regional health. Southeast Asia · 2022Article
- Higher maternal thyroid resistance indices were associated with increased neonatal thyroid-stimulating hormone- analyses based on the Huizhou mother-infant cohort.Frontiers in endocrinology · 2022Article
- Effect of Maternal Triclosan Exposure on Neonatal Thyroid-Stimulating Hormone Levels: A Cross-Sectional Study.Journal of environmental and public health · 2022Article
- Utility of the New Indian Society of Paediatric and Adolescent Endocrinology (ISPAE) Guidelines for Congenital Hypothyroidism Screening in a High Risk Unit.Indian journal of pediatrics · 2021Article
- Diagnostic Utility of Cord Blood Thyroid Stimulating Hormone in Congenital Hypothyroidism in the Era of Expanded Newborn Screening.Indian journal of clinical biochemistry : IJCB · 2018Article
- Perinatal factors associated with neonatal thyroid-stimulating hormone in normal newborns.Annals of pediatric endocrinology & metabolism · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCongenital hypothyroidism (CH) is most common preventable cause of mental retardation in children. Cord blood Thyroid Stimulating Hormone (CBTSH) level is an accepted screening tool for CH.
objectivesTo study CBTSH profile in neonates born at tertiary care referral center and to analyze the influence of maternal and neonatal factors on their levels.
designCross retrospective sectional study.
methodsStudy population included 979 neonates (males = 506 to females = 473). The CBTSH levels were estimated using electrochemiluminescence immunoassay on Cobas analyzer. Kit based cut-offs of TSH level were used for analysis. All neonates with abnormal CBSTH levels, were started on levothyroxine supplementation 10 μg/Kg/day and TSH levels were reassessed as per departmental protocol.
resultsThe mean CBTSH was 7.82 μIU/mL (Range 0.112 to 81.4, SD = 5.48). The mean CBTSH level was significantly higher in first order neonates, neonates delivered by assisted vaginal delivery and normal delivery, delivered at term or preterm, neonates with APGAR score <5 and those needing advanced resuscitation after birth. The CBTSH level >16.10 and <1.0 μIU/mL was found in 4.39 % and 1.02 % neonates respectively. The prevalence rate of CBTSH level >16.1 μIU/mL was significantly higher in neonates delivered by assisted vaginal delivery and normal delivery, term and preterm neonates, APAGR score of <5, presence of fetal distress, need for resuscitation beyond initial steps and in those with birth weight of <1.5 Kg. Three neonates were confirmed to have CH after retesting of TSH level.
conclusionsThe CBTSH estimation is an easy, non-invasive method for screening for CH. The cutoff level of CB TSH (μIU/mL) >16.10 and <1.0 led to a recall of 5.41% of neonates which is practicable given the scenario in our Country. The mode of delivery and perinatal stress factors have a significant impact on CBTSH levels and any rise to be seen in the light of these factors. The prevalence rate of CH after recall was ~3 in 1000 live births.
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