ArticleSpringerPlus2016
Timing of carbohydrate ingestion did not affect inflammatory response and exercise performance during prolonged intermittent running.
Article in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Fueling Soccer Players: A Scoping Review and Audit of Literature Related to Soccer-Specific Guidelines for Carbohydrate Intake.Sports medicine (Auckland, N.Z.) · 2025Article
- An investigation into how the timing of nutritional supplements affects the recovery from post-exercise fatigue: a systematic review and meta-analysis.Frontiers in nutrition · 2025Review
- International society of sports nutrition position stand: nutrient timing.Journal of the International Society of Sports Nutrition · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarbohydrate ingestion during exercise is known to attenuate exercise-induced elevation of plasma IL-6 concentration. However, the influence of timing of carbohydrate ingestion remains unclear. PURPOSE: The present study investigated the influence of different timing of carbohydrate ingestion during a simulated soccer game on exercise performance, metabolic and inflammatory responses.
methodsSeven active males performed 3 exercise trials in a randomized order. The exercise consisted of two consecutive bouts of 45 min running (4-16 km/h), separated with 15 min rest period between bouts. The subjects ingested carbohydrate gel (1.0 g/kg) immediately before the first bout of exercise (ONE), immediately before first and second bouts of exercise (0.5 g/kg for each ingestion) (TWO) or placebo immediately before exercise (PLA) Time course changes of maximal jump height, peak power output during 6-s maximal pedaling, perceived fatigue and heart rate (HR) were monitored. Blood samples were also drawn to determine blood glucose, serum insulin, free fatty acid (FFA), myoglobin (Mb), creatine kinase (CK) and plasma IL-6 concentrations.
resultsBlood glucose and serum insulin concentrations were significantly higher in the ONE trial after first bout of 45 min exercise compared with PLA trial (P < 0.05), while serum FFA concentration was significantly elevated in PLA compared with ONE and TWO trials after second bout of exercise (P < 0.05). However, changes of jump height, peak power output during 6-s maximal pedaling, perceived fatigue, HR, or indirect muscle damage (Mb, CK) and inflammatory (IL-6) markers were not significantly different among three trials (P > 0.05).
conclusionsThe timing of carbohydrate ingestion did not affect exercise performance, exercise-induced muscle damage or inflammatory response during a simulated soccer game.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.