ArticleAmerican journal of cancer research2016
PTTG promotes invasion in human breast cancer cell line by upregulating EMMPRIN via FAK/Akt/mTOR signaling.
Article in American journal of cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- RGS12 Represses Oral Cancer via the Phosphorylation and SUMOylation of PTEN.Journal of dental research · 2021Article
- Distinct expression pattern and prognostic values of pituitary tumor transforming gene family genes in non-small cell lung cancer.Oncology letters · 2019Article
- MiR-6875-3p promotes the proliferation, invasion and metastasis of hepatocellular carcinoma via BTG2/FAK/Akt pathway.Journal of experimental & clinical cancer research : CR · 2019Article
- PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer.Cancer research · 2018Article
- Expression of proteins associated with epithelial-mesenchymal transition in esophageal squamous cell carcinoma.Oncology letters · 2018Article
- SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer.Journal of Cancer · 2018Article
- Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer.Oncogene · 2017Article
- CSF-1R regulates non-small cell lung cancer cells dissemination through Wnt3a signaling.American journal of cancer research · 2017Article
- PLK1 promotes epithelial-mesenchymal transition and metastasis of gastric carcinoma cells.American journal of translational research · 2016Article
Corrections and comments
- Correction · 2020-04-01Error in Image · Updated to Retraction · · see also: https://scienceintegritydigest.com/2020/02/21/the-tadpole-paper-mill/
- Retraction · 2020-07-01Investigation by Third Party · Paper Mill · Plagiarism of/in Article · Upgrade/Update of Prior Notice(s) · · see also: https://scienceintegritydigest.com/2020/02/21/the-tadpole-paper-mill/
- Erratum issued
- Retracted
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pituitary tumor transforming gene (PTTG) is a novel oncogene that is expressed at higher level in most of the tumors. PTTG overexpression correlates with lymph node infiltration and a higher degree of tumor recurrence in breast cancer. However, the cellular functions and precise signals elicited by PTTG in breast cancer are not fully understood. Here, we established a breast cancer cell line which stably overexpressed PTTG. In vitro experiments showed that overexpression of PTTG in MCF-7 cells was associated with enhanced cell migration and invasion as well as EMT. Our results also demonstrated that PTTG overexpression correlated with elevated EMMPRIN level, which mediated the enhanced cell migration, invasion and EMT. Moreover, our findings suggested that PTTG enhances metastatic potential of breast cancer cells by inducing EMMPRIN through activating FAK/Akt/mTOR pathway. Our findings may lead to a better understanding of the biological effect of PTTG and provide mechanistic insights for developing potential therapeutic strategies for inhibiting the invasion and metastasis of breast cancer.
Indexed as
Identifiers
27186413PMC4859670W2410398124What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.