ArticleAmerican journal of translational research2016
Houttuynia cordata Thunb reverses oxaliplatin-induced neuropathic pain in rat by regulating Th17/Treg balance.
Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Immunomodulatory Effects of Medicinal Plants.Advances in experimental medicine and biology · 2026Review
- Nutraceutical prospects ofFood bioscience · 2022Article
- Integrated therapeutic plasma exchange and traditional Chinese medicine treatment in a patient with severe COVID-19: A case report.Journal of integrative medicine · 2022Article
- Pharmacological Effects ofPharmaceuticals (Basel, Switzerland) · 2022Review
- Probiotic Therapy (BIO-THREE) Mitigates Intestinal Microbial Imbalance and Intestinal Damage Caused by Oxaliplatin.Probiotics and antimicrobial proteins · 2022Article
- The Role of Vascular-Immune Interactions in Modulating Chemotherapy Induced Neuropathic Pain.Frontiers in pharmacology · 2022Article
- The Clinical Effect and Mechanism of Prostant on Urinary Retention and Anal Pain.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Therapeutic Agents for Oxaliplatin-Induced Peripheral Neuropathy; Experimental and Clinical Evidence.International journal of molecular sciences · 2021Review
- Review
- Neuroinflammatory Process Involved in Different Preclinical Models of Chemotherapy-Induced Peripheral Neuropathy.Frontiers in immunology · 2020Review
- Houttuynia cordata Thunb rescues retinal ganglion cells through inhibiting microglia activation in a rat model of retinal ischemia-reperfusion.International journal of ophthalmology · 2020Article
- Inhibitory effect of Houttuynia cordata Thunb on LPS-induced retinal microglial activation.International journal of ophthalmology · 2019Article
- Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy.Journal of pain research · 2019Article
- Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A review.Journal of ethnopharmacology · 2018Review
- Changes of Treg and Th17 cells as well as cytokines in children with acute bronchitis.Experimental and therapeutic medicine · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxaliplatin is a widely used anti-advanced colorectal cancer drug, while it could induce neuropathy. Houttuynia cordata Thunb (HCT) has a wide range of biological activities, such as anti-inflammation, anti-cancer, and immune regulation. In the present study, we investigated the effect of HCT on oxaliplatin-induced neuropathy in rat models. HCT (1000 mg/kg/day) significantly decreased the number of withdrawal responses and the withdrawal latency in oxaliplatin-treated rats. HCT could down-regulated the serum levels of Interleukin-6 (IL-6) and macrophage inflammatory protein1-α (MIP-1α) in oxaliplatin-treated rats. Th17/Treg balance was reversed by HCT in oxaliplatin-treated rats by regulating PI3K/Akt/mTOR signaling pathway. The present results suggest that HCT is useful as a therapeutic drug for oxaliplatin-induced neuropathic pain.
Indexed as
Identifiers
27186286PMC4859645What OpenQuestion holds
Registered trials
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