ArticleAmerican journal of translational research2016
MicroRNA-217 inhibits cell proliferation and invasion by targeting Runx2 in human glioma.
Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Oncogenic role of microRNA-19b-3p-mediated SOCS3 in glioma through activation of JAK-STAT pathway.Metabolic brain disease · 2023Article
- Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis.Experimental & molecular medicine · 2023Article
- miR-217-5p suppresses epithelial-mesenchymal transition and the NF-κB signaling pathway in breast cancer via targeting of metadherin.Oncology letters · 2022Article
- WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circular RNAs That Interact with RNA-Binding Proteins and Sponge miRNAs.International journal of general medicine · 2021Article
- Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data.Genome biology · 2020Article
- LncRNA DLX6-AS1 aggravates the development of ovarian cancer via modulating FHL2 by sponging miR-195-5p.Cancer cell international · 2020Article
- Inhibition of human cervical cancer cell invasion by IL-37 involving runt related transcription factor 2 suppression.Annals of translational medicine · 2019Article
- The Differential Expression of miRNAs and a Preliminary Study on the Mechanism of miR-194-3p in Keloids.BioMed research international · 2019Article
- Long noncoding RNA DLEU1 aggravates glioma progression via the miR-421/MEF2D axis.OncoTargets and therapy · 2019Article
- miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells.Journal of cell communication and signaling · 2018Article
- Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration.Cell death & disease · 2018Article
- Downregulated miR-217 expression predicts a poor outcome in acute myeloid leukemia.Cancer biomarkers : section A of Disease markers · 2018Article
- miR-505 functions as a tumor suppressor in glioma by targeting insulin like growth factor 1 receptor expression.International journal of clinical and experimental pathology · 2018Article
- Polymorphisms of rs1347093 and rs1397529 are associated with lung cancer risk in northeast Chinese population.Oncotarget · 2017Article
- miR-217-casein kinase-2 cross talk regulates ERK activation in ganglioglioma.Journal of molecular medicine (Berlin, Germany) · 2017Article
- MiR-302b Suppresses Osteosarcoma Cell Migration and Invasion by Targeting Runx2.Scientific reports · 2017Article
- miR-217 inhibits laryngeal cancer metastasis by repressing AEG-1 and PD-L1 expression.Oncotarget · 2017Article
- miR-543 functions as a tumor suppressor in glioma in vitro and in vivo.Oncology reports · 2017Article
- miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5.PloS one · 2017Article
- MicroRNA-520d-5p inhibits human glioma cell proliferation and induces cell cycle arrest by directly targeting PTTG1.American journal of translational research · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MircroRNA-217 (miR-217) has been showed to involve in the initiation and development of human cancers, and is recognize as a tumor suppressor miRNA in several tumors. However, the clinical significance and its underlying role in human glioma remain unclear. Herein, we found that the expression of miR-217 was significantly down-regulated in glioma tissues as compared with adjacent normal brain tissues. Clinical association analysis disclosed that low-expression of miR-217 was evidently negative associated with advanced tumor stage (grade III + IV) in glioma. Further function assays showed that miR-217 inhibited proliferation, colony formation, invasion and migration of glioma cells. Notably, runt-related transcription factors 2 (Runx2) was identified as a functional target of miR-217 in glioma. Furthermore, an inverse correlation between miR-217 and Runx2 expression was observed in glioma tissues. Downregulation of Runx2 has similar with inhibition effect of overexpression of miR-217, and upregulation of Runx2 reversed the effects of overexpressing of miR-217. Taken together, these results suggest a critical role of miR-217 in suppressing proliferation, migration, and invasion of glioma by targeting Runx2.
Indexed as
Identifiers
27186274PMC4859633W2466117248What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.