ArticleProceedings of the National Academy of Sciences of the United States of America2016
Transient neuronal coactivations embedded in globally propagating waves underlie resting-state functional connectivity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 1 of them a synthesis that pooled it.
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122 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Aberrant brain network connectivity in presymptomatic and manifest Huntington's disease: A systematic review.Human brain mapping · 2020Pooled it
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- HESREN: A Derivative-Informed Reservoir Framework for Detecting Transient Neural Events and Windowless Estimation of Dynamic Functional Connectivity.Neuroinformatics · 2026Article
- Psilocybin shapes the slow, global propagation of brain activity over the cortical layout of 5HT2a receptors.Communications biology · 2026Article
- Neural barcoding representing cortical spatiotemporal dynamics based on continuous-time Markov chains.Cell reports methods · 2026Article
- Sensory encoding and memory retrieval are coordinated with propagating waves in the human brain.Nature communications · 2026Article
- An evaluation of the efficacy of single-echo and multi-echo fMRI denoising strategies.Network neuroscience (Cambridge, Mass.) · 2026Article
- Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input.Nature communications · 2025Article
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- Time-resolved large-scale neural coactivations in macaque monkey.NeuroImage · 2025Article
- Neuromodulatory influences on propagation of traveling waves along the unimodal-transmodal gradient.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
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- Time-Varying Spatial Propagation of Brain Networks in fMRI Data.Human brain mapping · 2025Article
- Neurovascular coupling: a review of spontaneous neocortical dynamics linking neuronal activity to hemodynamics and what we have learned from the rodent brain.Journal of neurophysiology · 2025Review
- The efficacy of resting-state fMRI denoising pipelines for motion correction and behavioural prediction.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Topographic correspondence between retinotopic and whisker somatosensory map in mouse higher visual area and its development.Frontiers in neural circuits · 2025Article
- Orthogonalization of spontaneous and stimulus-driven activity by hierarchical neocortical areal network in primates.Nature communications · 2024Article
- Attention-based CNN-BiLSTM for sleep state classification of spatiotemporal wide-field calcium imaging data.Journal of neuroscience methods · 2024Article
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
62 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
Resting-state functional connectivity (FC), which measures the correlation of spontaneous hemodynamic signals (HemoS) between brain areas, is widely used to study brain networks noninvasively. It is commonly assumed that spatial patterns of HemoS-based FC (Hemo-FC) reflect large-scale dynamics of underlying neuronal activity. To date, studies of spontaneous neuronal activity cataloged heterogeneous types of events ranging from waves of activity spanning the entire neocortex to flash-like activations of a set of anatomically connected cortical areas. However, it remains unclear how these various types of large-scale dynamics are interrelated. More importantly, whether each type of large-scale dynamics contributes to Hemo-FC has not been explored. Here, we addressed these questions by simultaneously monitoring neuronal calcium signals (CaS) and HemoS in the entire neocortex of mice at high spatiotemporal resolution. We found a significant relationship between two seemingly different types of large-scale spontaneous neuronal activity-namely, global waves propagating across the neocortex and transient coactivations among cortical areas sharing high FC. Different sets of cortical areas, sharing high FC within each set, were coactivated at different timings of the propagating global waves, suggesting that spatial information of cortical network characterized by FC was embedded in the phase of the global waves. Furthermore, we confirmed that such transient coactivations in CaS were indeed converted into spatially similar coactivations in HemoS and were necessary to sustain the spatial structure of Hemo-FC. These results explain how global waves of spontaneous neuronal activity propagating across large-scale cortical network contribute to Hemo-FC in the resting state.
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