ArticleProceedings of the National Academy of Sciences of the United States of America2016
Target shape dependence in a simple model of receptor-mediated endocytosis and phagocytosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Entropy-Driven Initiation and Cytoskeletal Viscoelasticity in Endocytosis: An Onsager Variational Framework.Membranes · 2026Article
- A biophysical model of phagocytic cup dynamics: The effect of membrane tension.PLoS computational biology · 2026Article
- Hybrid Physics-Informed and Bayesian Modeling of Single-Nanoparticle-Cell Adhesion Kinetics under Cytoskeletal Perturbation.Computational and structural biotechnology journal · 2026Article
- Resident phagocytes promote non-cell-autonomous fragmentation of apoptotic cells.Science advances · 2025Article
- Challenges and opportunities in the application of carbon nanotubes as membrane channels to improve mass transfer to cells.RSC advances · 2025Review
- Highly variable aggregation and glycosylation profiles and their roles in immunogenicity to protein-based therapeutics.Journal of pharmaceutical sciences · 2025Review
- Measurement of macrophage phagocytic capacity by quantifying maximum membrane extension using an opsonized capillary tube assay.Scientific reports · 2025Article
- Biomechanics of phagocytosis of red blood cells by macrophages in the human spleen.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Two-component macrophage model for active phagocytosis with pseudopod formation.Biophysical journal · 2024Article
- Biaxial Structures of Localized Deformations and Line-like Distortions in Effectively 2D Nematic Films.Nanomaterials (Basel, Switzerland) · 2024Article
- Wrapping Pathways of Anisotropic Dumbbell Particles by Giant Unilamellar Vesicles.Nano letters · 2023Article
- The spatial resolution limit of phagocytosis.Biophysical journal · 2023Article
- Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces.Soft matter · 2022Article
- Role of particle local curvature in cellular wrapping.Journal of the Royal Society, Interface · 2022Article
- Integrative experimental/computational approach establishes active cellular protrusion as the primary driving force of phagocytic spreading by immune cells.PLoS computational biology · 2022Article
- Understanding the Phagocytosis of Particles: the Key for Rational Design of Vaccines and Therapeutics.Pharmaceutical research · 2022Review
- Study of tribological properties of human buccal epithelium cell membranes using probe microscopy.Scientific reports · 2022Article
- Article
- Role of Ligand Distribution in the Cytoskeleton-Associated Endocytosis of Ellipsoidal Nanoparticles.Membranes · 2021Article
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2 authors.
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Abstract
Phagocytosis and receptor-mediated endocytosis are vitally important particle uptake mechanisms in many cell types, ranging from single-cell organisms to immune cells. In both processes, engulfment by the cell depends critically on both particle shape and orientation. However, most previous theoretical work has focused only on spherical particles and hence disregards the wide-ranging particle shapes occurring in nature, such as those of bacteria. Here, by implementing a simple model in one and two dimensions, we compare and contrast receptor-mediated endocytosis and phagocytosis for a range of biologically relevant shapes, including spheres, ellipsoids, capped cylinders, and hourglasses. We find a whole range of different engulfment behaviors with some ellipsoids engulfing faster than spheres, and that phagocytosis is able to engulf a greater range of target shapes than other types of endocytosis. Further, the 2D model can explain why some nonspherical particles engulf fastest (not at all) when presented to the membrane tip-first (lying flat). Our work reveals how some bacteria may avoid being internalized simply because of their shape, and suggests shapes for optimal drug delivery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.