ArticleCurrent biology : CB2016
Multiple Time Courses of Vestibular Set-Point Adaptation Revealed by Sustained Magnetic Field Stimulation of the Labyrinth.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Classification of vestibular signs and examination techniques: Nystagmus and nystagmus-like movements.Journal of vestibular research : equilibrium & orientationGuideline
- Study on the regulatory effect of magnetic vestibular stimulation on visually induced motion sickness.Medical & biological engineering & computing · 2026Article
- Pathophysiological Variants of Horizontal Semicircular Canal Benign Paroxysmal Positional Vertigo: Toward an Integrative Model Based on Otoconial Location and Cupular Dynamics.Audiology research · 2026Review
- Electromagnetic fields regulate iron metabolism: From mechanisms to applications.Journal of advanced research · 2026Review
- Modeling of magnetic vestibular stimulation experienced during high-field clinical MRI.Communications medicine · 2025Article
- Induced electric fields in MRI settings and electric vestibular stimulations: same vestibular effects?Experimental brain research · 2024Review
- Cupulolithiatic BPPV involving both posterior semicircular canals: implications for set-point adaptation.Journal of neurology · 2024Article
- Visual Fixation of Skull-Vibration-Induced Nystagmus in Patients with Peripheral Vestibulopathy.Audiology research · 2024Article
- Sustained bias of spatial attention in a 3 T MRI scanner.Scientific reports · 2024Article
- Longer duration entry mitigates nystagmus and vertigo in 7-Tesla MRI.Frontiers in neurology · 2023Article
- Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium.iScience · 2022Article
- Persistent horizontal and vertical, MR-induced nystagmus in resting state Human Connectome Project data.NeuroImage · 2022Article
- "Sitting-up vertigo as an expression of posterior semicircular canal heavy cupula and posterior semicircular canal short arm canalolithiasis".Journal of otology · 2022Article
- Inappropriate Ventilatory Homeostatic Responses in Hospitalized COVID-19 Patients.Frontiers in neurology · 2022Article
- New Frontiers in Managing the Dizzy Patient.Otolaryngologic clinics of North America · 2021Review
- Article
- Modulatory effects of magnetic vestibular stimulation on resting-state networks can be explained by subject-specific orientation of inner-ear anatomy in the MR static magnetic field.Journal of neurology · 2020Article
- Horizontal semicircular canal jam: Two new cases and possible mechanisms.Laryngoscope investigative otolaryngology · 2020Article
- Unusual Vestibulo-Ocular Reflex Responses in Patients With Peripheral Vestibular Disorders Detected by the Caloric Step Stimulus Test.Frontiers in neurology · 2020Article
- Short-Term Central Adaptation in Benign Paroxysmal Positional Vertigo.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
A major focus in neurobiology is how the brain adapts its motor behavior to changes in its internal and external environments [1, 2]. Much is known about adaptively optimizing the amplitude and direction of eye and limb movements, for example, but little is known about another essential form of learning, "set-point" adaptation. Set-point adaptation balances tonic activity so that reciprocally acting, agonist and antagonist muscles have a stable platform from which to launch accurate movements. Here, we use the vestibulo-ocular reflex-a simple behavior that stabilizes the position of the eye while the head is moving-to investigate how tonic activity is adapted toward a new set point to prevent eye drift when the head is still [3, 4]. Set-point adaptation was elicited with magneto-hydrodynamic vestibular stimulation (MVS) by placing normal humans in a 7T MRI for 90 min. MVS is ideal for prolonged labyrinthine activation because it mimics constant head acceleration and induces a sustained nystagmus similar to natural vestibular lesions [5, 6]. The MVS-induced nystagmus diminished slowly but incompletely over multiple timescales. We propose a new adaptation hypothesis, using a cascade of imperfect mathematical integrators, that reproduces the response to MVS (and more natural chair rotations), including the gradual decrease in nystagmus as the set point changes over progressively longer time courses. MVS set-point adaptation is a biological model with applications to basic neurophysiological research into all types of movements [7], functional brain imaging [8], and treatment of vestibular and higher-level attentional disorders by introducing new biases to counteract pathological ones [9].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.