ArticleScientific reports2016
Improved sensitivity of computed tomography towards iodine and gold nanoparticle contrast agents via iterative reconstruction methods.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Review
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- Advances in Ultrasmall Inorganic Nanoparticles for Nanomedicine: From Diagnosis to Therapeutics.ACS applied materials & interfaces · 2025Review
- Article
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- Image quality characterization of an ultra-high-speed kilovoltage cone-beam computed tomography imaging system on an O-ring linear accelerator.Journal of applied clinical medical physics · 2024Article
- Multispectral optoacoustic tomography is more sensitive than micro-computed tomography for tracking gold nanorod labelled mesenchymal stromal cells.Journal of biophotonics · 2023Article
- Non-radioactive imaging strategies forPhysical sciences reviews · 2023Article
- Treasure on the Earth-Gold Nanoparticles and Their Biomedical Applications.Materials (Basel, Switzerland) · 2022Review
- Observation of targeted gold nanoparticles in nasopharyngeal tumour nude mice model through dual-energy computed tomography.IET nanobiotechnology · 2021Article
- Recent Advances in Molecular Imaging with Gold Nanoparticles.Bioconjugate chemistry · 2020Review
- Finely crafted quasi-core-shell gadolinium/layered double hydroxide hybrids for switching on/off bimodal CT/MRI contrasting nanodiagnostic platforms.RSC advances · 2020Article
- Multicolor spectral photon counting CT monitors and quantifies therapeutic cells and their encapsulating scaffold in a model of brain damage.Nanotheranostics · 2020Article
- Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography.Scientific reports · 2019Article
- In Vivo Tracking of Tissue Engineered Constructs.Micromachines · 2019Review
- Investigation of transmission computed tomography (CT) image quality and x-ray dose achievable from an experimental dual-mode benchtop x-ray fluorescence CT and transmission CT system.Journal of X-ray science and technology · 2019Article
- Potential applications of engineered nanoparticles in medicine and biology: an update.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018Review
- Assessment of candidate elements for development of spectral photon-counting CT specific contrast agents.Scientific reports · 2018Article
- Recent Development of Inorganic Nanoparticles for Biomedical Imaging.ACS central science · 2018Review
- Toxicology of Engineered Nanoparticles: Focus on Poly(amidoamine) Dendrimers.International journal of environmental research and public health · 2018Review
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Authors and funding
8 authors.
Funding
Abstract
Computed tomography is a widely used medical imaging technique that has high spatial and temporal resolution. Its weakness is its low sensitivity towards contrast media. Iterative reconstruction techniques (ITER) have recently become available, which provide reduced image noise compared with traditional filtered back-projection methods (FBP), which may allow the sensitivity of CT to be improved, however this effect has not been studied in detail. We scanned phantoms containing either an iodine contrast agent or gold nanoparticles. We used a range of tube voltages and currents. We performed reconstruction with FBP, ITER and a novel, iterative, modal-based reconstruction (IMR) algorithm. We found that noise decreased in an algorithm dependent manner (FBP > ITER > IMR) for every scan and that no differences were observed in attenuation rates of the agents. The contrast to noise ratio (CNR) of iodine was highest at 80 kV, whilst the CNR for gold was highest at 140 kV. The CNR of IMR images was almost tenfold higher than that of FBP images. Similar trends were found in dual energy images formed using these algorithms. In conclusion, IMR-based reconstruction techniques will allow contrast agents to be detected with greater sensitivity, and may allow lower contrast agent doses to be used.
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Registered trials
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