ArticleeLife2016
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer.
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Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
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38 citing papers in PubMed, 82 citations in OpenAlex.
- Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression.Cancer research · 2026Article
- Mitogenomic sequencing of the Brazilian Mastiff and Brazilian Terrier suggests a complex scenario of breed formation for two established Brazilian dog breeds.Genetics and molecular biology · 2026Article
- Comparative Genetics of Canine and Human Cancers.Veterinary sciences · 2025Review
- The Complete Mitochondrial Genome of the Deep-Dwelling GobyInternational journal of molecular sciences · 2025Article
- Ancient dog mitogenomes support the dual dispersal of dogs and agriculture into South America.Proceedings. Biological sciences · 2025Article
- Horizontal transfer of nuclear DNA in transmissible cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Defects in the Mitochondrial Genome of Dogs with Recurrent Tumours.International journal of molecular sciences · 2024Article
- Article
- Whole Mitochondrial Genome Sequencing Analysis of Canine Testicular Tumours.International journal of molecular sciences · 2024Article
- Exploring the limitations of mitochondrial dye as a genuine horizontal mitochondrial transfer surrogate.Communications biology · 2024Article
- Review of Molecular Technologies for Investigating Canine Cancer.Animals : an open access journal from MDPI · 2024Review
- Mitochondria on the move: Horizontal mitochondrial transfer in disease and health.The Journal of cell biology · 2023Article
- REC drives recombination to repair double-strand breaks in animal mtDNA.The Journal of cell biology · 2023Article
- Sex disparity in oronasal presentations of canine transmissible venereal tumour.The Veterinary record · 2022Article
- Prevalence and polymorphism of a mussel transmissible cancer in Europe.Molecular ecology · 2022Article
- Article
- Small extracellular vesicle DNA-mediated horizontal gene transfer as a driving force for tumor evolution: Facts and riddles.Frontiers in oncology · 2022Review
- Genomics and transcriptomics in veterinary oncology.Oncology letters · 2021Review
- First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself.Scientific reports · 2021Article
- Origins and genetic legacy of prehistoric dogs.Science (New York, N.Y.) · 2020Article
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Authors and funding
62 authors at 20 institutions in 29 countries.
Andrea StrakovaDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Máire Ní LeathlobhairDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Guo-Dong WangState Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Ting-Ting YinState Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Ilona Airikkala-OtterInternational Training Center, Worldwide Veterinary Service, Aruvankadu, India.
Janice L AllenAnimal Management in Rural and Remote Indigenous Communities, Darwin, Australia.
Karen M AllumWorld Vets, Fargo, United States.
Leontine Bansse-IssaStichting Dierenbescherming Suriname, Paramaribo, Suriname.
Jocelyn L BissonDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Artemio Castillo DomrachevaCorozal Veterinary Hospital, University of Panama, Panama City, Panama.
Karina F de CastroDepartment of Clinical and Veterinary Surgery, São Paulo State University, São Paulo, Brazil.
Anne M CorriganSt. George's University, True Blue, Grenada.
Hugh R CranThe Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya.
Jane T CrawfordAnimal Medical Centre, Belize City, Belize.
Stephen M CutterAnimal Management in Rural and Remote Indigenous Communities, Darwin, Australia.
Laura Delgadillo KeenanVeterinary clinic Sr. Dog's, Guadalajara, Mexico.
Edward M DonelanAnimal Management in Rural and Remote Indigenous Communities, Darwin, Australia.
Ibikunle A FaramadeNational Veterinary Research Institute, Vom, Nigeria.
Erika Flores ReynosoInternational Fund for Animal Welfare, Quintana Roo, Mexico.
Eleni FotopoulouIntermunicipal Stray Animals Care Centre, Perama, Greece.
Skye N FrueanAnimal Protection Society of Samoa, Apia, Samoa.
Fanny Gallardo-ArrietaFaculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela.
Olga GlebovaVeterinary clinic BIOCONTROL, Moscow, Russia.
Rodrigo F Häfelin ManriqueVeterinary clinic El Roble, Santiago de Chile, Chile.
Joaquim Jgp HenriquesOnevetGroup, Centro Veterinário Berna, Lisboa, Portugal.
Natalia IgnatenkoVeterinary clinic Zoovetservis, Kiev, Ukraine.
Debbie KoenigWorld Vets, Fargo, United States.
Marta Lanza-PereaSt. George's University, True Blue, Grenada.
Remo LobettiBryanston Veterinary Hospital, Bryanston, South Africa.
Adriana M Lopez QuintanaVeterinary Clinic Lopez Quintana, Maldonado, Uruguay.
Thibault LosfeltClinique Veterinaire de Grand Fond, Saint Gilles les Bains, France.
Gabriele MarinoDepartment of Veterinary Sciences, University of Messina, Messina, Italy.
Inigo MartincorenaWellcome Trust Sanger Institute, Hinxton, United Kingdom.
Simón Martínez CastañedaFacultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.
Mayra F Martínez-LópezSchool of Veterinary Medicine, Universidad de las Américas, Quito, Ecuador.
Michael MeyerTouray & Meyer Vet Clinic, Serrekunda, Gambia.
Berna NakanwagiThe Kampala Veterinary Surgery, Kampala, Uganda.
Andrigo B De NardiDepartment of Clinical and Veterinary Surgery, São Paulo State University, São Paulo, Brazil.
Winifred NeunzigWorld Vets, Fargo, United States.
Sally J NixonVets Beyond Borders, The Rocks, Australia.
Marsden M OnsareAniworld veterinary clinic, Kisumu, Kenya.
Antonio Ortega-PachecoFaculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico.
Maria C PeleteiroInterdisciplinary Centre of Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal.
Ruth J PyeVets Beyond Borders, The Rocks, Australia.
John F ReeceHelp in Suffering, Jaipur, India.
Jose Rojas GutierrezVeterinary clinic Dr José Rojas, Los Andes, Chile.
Haleema SadiaUniversity of Veterinary and Animal Sciences, Lahore, Pakistan.
Sheila K SchmelingCorozal Veterinary Clinic, Corozal Town, Belize.
Olga ShamanovaVeterinary clinic Vetmaster, Ramenskoye, Russia.
Richard K SsunaLilongwe Society for Protection and Care of Animals, Lilongwe, Malawi.
Audrey E Steenland-SmitStichting Dierenbescherming Suriname, Paramaribo, Suriname.
Alla SvitichState Hospital of Veterinary Medicine, Dniprodzerzhynsk, Ukraine.
Ismail Thoya NgokaKenya Society for Protection and Care of Animals, Nairobi, Kenya.
Bogdan A VițălaruClinical Sciences Department, Faculty of Veterinary Medicine, Bucharest, Romania.
Anna P de VosLadybrand Animal Clinic, Ladybrand, South Africa.
Johan P de VosVeterinary Oncology Referral Centre De Ottenhorst, Terneuzen, Netherlands.
Oliver WalkintonVets Beyond Borders, The Rocks, Australia.
David C WedgeWellcome Trust Sanger Institute, Hinxton, United Kingdom.
Alvaro S Wehrle-MartinezFaculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, Paraguay.
Mirjam G van der WelAnimal Anti Cruelty League, Port Elizabeth, South Africa.
Sophie Ae WiddowsonLilongwe Society for Protection and Care of Animals, Lilongwe, Malawi.
Elizabeth P MurchisonDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-7462-8907
University of Cambridge · GBAustralian College of Rural and Remote Medicine · AUWells Fargo (United States) · USKunming Institute of Zoology · CNMulti Electrical System (Suriname) · SRSt. George's University · GDUniversidade Estadual Paulista (Unesp) · BRWellcome Sanger Institute · GBAga Khan Hospital, Kisumu · KEAT Sciences (United States) · USAutonomous University of Yucatán · MXBiocon (Switzerland) · CHBrides-les-Bains · FRCentral America Health Sciences University · BZCentro Hospitalar de Lisboa Ocidental · PTDniprovsk State Technical University · UADow Chemical (Netherlands) · NLHospital Clínico de la Universidad de Chile · CLInternational Fund for Animal Welfare · USJohannesburg Wildlife Vet · ZA
Funding
Wellcome TrustWellcome Trust 102942/Z/13/A
Abstract
Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.
Indexed as
Genetic VariationRecombination, GeneticSelection, GeneticAnimalsDNA, MitochondrialDog DiseasesDogsMitochondriaSequence Analysis, DNAVenereal Tumors, VeterinaryDNA, Mitochondrialcancer biologycanine transmissible venereal tumourDogevolutionary biologygenomicsmitochondriatransmissible cancer
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.