SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016
Stroke increases the risk of hip fracture: a systematic review and meta-analysis.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Does atrial fibrillation increase the risk of fractures? A systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- [Osteoporosis-Definition, risk assessment, diagnosis, prevention and treatment (update 2024) : Guidelines of the Austrian Society for Bone and Mineral Research].Wiener klinische Wochenschrift · 2024Guideline
- The Epidemiology of Hip Fracture among Subjects with Pyogenic Liver Abscess (PLA): A Nationwide Population-Based Study.BioMed research international · 2020Trial
- Establishment and validation of a clinical prediction model for perioperative pneumonia in elderly patients with hip fractures combined with preoperative stroke.Frontiers in medicine · 2026Article
- Design and Validation of a Brain-Controlled Hip Exoskeleton for Assisted Gait Rehabilitation Training.Micromachines · 2025Article
- Does the rate of hip abductor and adductor muscle activation during weight transfer influence voluntary lateral stepping in chronic stroke?Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2025Article
- An exploration of serious falls after stroke using a large international stroke rehabilitation database.International journal of stroke : official journal of the International Stroke Society · 2025Article
- A Higher Charlson Comorbidity Index Is a Risk Factor for Hip Fracture in Older Adults During Low-Temperature Periods: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2024Article
- The incidence and risk factors of perioperative recurrent stroke in elderly patients with previous ischemic stroke receiving hip fracture surgery.BMC musculoskeletal disorders · 2024Article
- Association Between Changes in Smoking Habits and Incident Fracture After Acute Ischemic Stroke.Journal of the American Heart Association · 2024Article
- Development and validation of common data model-based fracture prediction model using machine learning algorithm.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- New-onset stroke on the risk of hip fracture: the Kailuan cohort study in China.BMC public health · 2023Article
- The association between peripheral arterial disease and risk for hip fractures in elderly men is not explained by low hip bone mineral density. Results from the MrOS Sweden study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Observational
- Cumulative Risk And Associated Factors For Fall-Related Fractures In Stroke Survivors After Discharge From Rehabilitation Wards: A Retrospective Study With A 6-Year Follow-Up.Journal of rehabilitation medicine · 2022Article
- Characteristics of Fall-Related Fractures in Older Adults with Cerebrovascular Disease: A Cross-Sectional Study.Clinical interventions in aging · 2021Article
- Osteoporotic fracture rates in chronic hemodialysis and effect of heparin exposure: a retrospective cohort study.BMC nephrology · 2020Article
- Pre-Existing Disability and Its Risk of Fragility Hip Fracture in Older Adults.International journal of environmental research and public health · 2019Article
- Epidemiology of hip fractures : Systematic literature review of German data and an overview of the international literature.Zeitschrift fur Gerontologie und Geriatrie · 2019Review
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies have investigated the association between stroke and hip fracture risk, but the precise association was still unclear due to insufficient statistical power in single studies with relatively small sample size. Thus, we firstly conducted a meta-analysis of all published studies to precisely estimate the relationship of stroke with hip fracture risk. The strength for this relationship was weighed by pooled relative risks (RRs) with 95 % confidence intervals (95 % CIs) after adjustment for confounding variables. Stratified analyses by study design and ethnicity and sensitivity analysis were also performed. Two investigators independently performed a comprehensive literature search in databases of PubMed, Embase, and Wanfang for eligible articles. A Bayesian meta-analysis was also performed to get a more precise assessment of the relationship. Eleven relevant studies from 10 publications were finally included into our meta-analysis according to the inclusion criteria. Overall, stroke significantly and independently increased the risk of hip fracture (RR = 2.06, 95 % CI 1.68-2.52, P < 0.001). Bayesian meta-analysis showed that stroke was also associated with an over two-fold increased risk of hip fracture (RR = 2.11, 95 % CI 1.62-2.75). In stratified analysis, stroke could increase the risk of hip fracture in Caucasians (RR = 2.36, 95 % CI 1.83-3.05, P < 0.001). These data support the notion that stroke is an independent risk factor for hip fracture, and patients with stroke have a two-fold increased risk of hip fracture than those without stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.