ArticleMicrobiologyOpen2016
Effects of human serum and apo-Transferrin on Staphylococcus epidermidis RP62A biofilm formation.
Article in MicrobiologyOpen, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
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- Omp34-MediatedAnalytical cellular pathology (Amsterdam) · 2025Article
- Host Soluble Factors Cause Changes inPathogens (Basel, Switzerland) · 2023Article
- Inhibitory effects of simeprevir onZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Bactericidal and anti-biofilm effects of uncharged and cationic ultrasound-responsive nitric oxide microbubbles onFrontiers in cellular and infection microbiology · 2022Article
- Regulatory role of the RstB-RstA system in adhesion, biofilm production, motility, and hemolysis.MicrobiologyOpen · 2018Article
- Interdependence between iron acquisition and biofilm formation in Pseudomonas aeruginosa.Journal of microbiology (Seoul, Korea) · 2018Review
- Plasma, serum, albumin, and divalent metal ions inhibit the adhesion and the biofilm formation ofAIMS microbiology · 2018Article
- Contributions of the oligopeptide permeases in multistep of Vibrio alginolyticus pathogenesis.MicrobiologyOpen · 2017Article
- Determinants for persistence of Pseudomonas aeruginosa in hospitals: interplay between resistance, virulence and biofilm formation.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Effects of human serum and apo-Transferrin on Staphylococcus epidermidis RP62A biofilm formation.MicrobiologyOpen · 2016Article
- Titanium Kirschner Wires Resist Biofilms Better Than Stainless Steel and Hydroxyapatite-coated Wires: AnStrategies in trauma and limb reconstructionArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biofilm-associated Staphylococcus epidermidis infections present clinically important features due to their high levels of resistance to traditional antibiotics. As a part of human innate immune system, serum shows different degrees of protection against systemic S. epidermidis infection. We investigated the ability of human serum as well as serum component to inhibit the formation of, and eradication of mature S. epidermidis biofilms. In addition, the synergistic effect of vancomycin combined with apo-Transferrin was checked. Human serum exhibited significant antibiofilm activities against S. epidermidis at the concentration without affecting planktonic cell growth. However, there was no effect of human serum on established biofilms. By component separation, we observed that antibiofilm effect of serum components mainly due to the proteins could be damaged by heat inactivation (e.g., complement) or heat-stable proteins ≥100 kDa. In addition, serum apo-Transferrin showed modest antibiofilm effect, but without influence on S. epidermidis initial adhesion. And there was a synergistic antibiofilm interaction between vancomycin and apo-Transferrin against S. epidermidis. Our results indicate that serum or its components (heat-inactivated components or heat-stable proteins ≥100 kDa) could inhibits S. epidermidis biofilm formation. Besides, apo-Transferrin could partially reduce the biofilm formation at the concentration that does not inhibit planktonic cell growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.