Evidence map›Paper›PMID 27185267›Full record

ArticleBiology open2016

Effects of TiO2 nanoparticles on nutrition metabolism in silkworm fat body.

J H Tian, J S Hu, F C Li, M Ni, Y Y Li, B B Wang, K Z Xu, W D Shen, B Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Silkworm, Bombyx mori, as an alternative model organism in toxicological research.Environmental science and pollution research international · 2018
    Article
  3. Silkworm: A Promising Model Organism in Life Science.Journal of insect science (Online) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

J H TianSchool of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu 215123, China National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, China.
J S HuSchool of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu 215123, China National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, China.
F C LiSchool of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu 215123, China National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, China.
M NiSchool of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu 215123, China National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, China.
Y Y LiSchool of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu 215123, China National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, China.
B B WangSchool of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu 215123, China National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, China.
K Z XuSchool of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu 215123, China National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, China.
W D ShenSchool of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu 215123, China National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, China.
B LiSchool of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu 215123, China National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, China lib@suda.edu.cn.ORCID http://orcid.org/0000-0001-6504-2728
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silkworm (Bombyx mori) is an important economic insect with a fat body that plays a crucial role in the storage and transfer of nutrients. It is also known that TiO2 nanoparticles (NPs) can improve feed efficiency and promote silk protein synthesis in the silkworm. In this study, we profiled gene expression in the silkworm fat body after TiO2 NP treatment, validated the major RNA-seq findings, and determined the contents of trehalose and triglyceride, the activity of lipase, and the amount of total proteins. RNA-seq analysis revealed that TiO2 NP treatment caused significant expression changes in 341 genes (P≤0.01), 138 of which were upregulated while the other 203 were downregulated. The expression levels of two target genes in the insulin signaling pathway and two protein metabolism-related target genes, three lipid metabolism-associated target genes, two carbohydrate metabolism related target genes and expression levels of seven heat shock protein genes were increased, and that of threonine dehydratase gene and fatty acid transport protein gene were decreased. The RNA-seq results of 16 genes were validated by quantitative real-time PCR. The lipase activity, content of trehalose, and amount of total proteins were elevated by 3.86-fold, 1.34-fold, and 1.21-fold, respectively, and the content of triglyceride was decreased by 0.94-fold after TiO2 NP treatment. These results indicated that TiO2 NPs activated the insulin signaling pathway, promoted the metabolism of protein, fat, and carbohydrate, and improved nutrition metabolism. Our study provides new support for the understanding of the beneficial effect of TiO2 NPs on silkworm nutrient metabolism.

Indexed as

Fat bodyNutrient metabolismSilkwormTiO2 NPs

Identifiers

PMID27185267
PMCPMC4920180
OpenAlexW2378646835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.