Evidence map›Paper›PMID 27185208›Full record

ArticleAmerican journal of hematology2016

Homozygosity for a haplotype in the HBG2-OR51B4 region is exclusive to Arab-Indian haplotype sickle cell anemia.

Vinod Vathipadiekal, Abdulrahman Alsultan, Kristin Baltrusaitis, John J Farrell, Abdullah M Al-Rubaish, Fahad Al-Muhanna, Zaki Naserullah, Ahmed Suliman, P K Patra, Jacqueline N Milton and 5 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Sickle cell disease in the era of precision medicine: looking to the future.Expert review of precision medicine and drug development · 2019
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vinod VathipadiekalDepartment of Medicine, Boston University School of Medicine, Boston, Massachusetts.
Abdulrahman AlsultanSickle Cell Disease Research Center and Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Kristin BaltrusaitisDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
John J FarrellDepartment of Medicine, Boston University School of Medicine, Boston, Massachusetts.
Abdullah M Al-RubaishDepartment of Internal Medicine, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia.
Fahad Al-MuhannaDepartment of Internal Medicine, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia.
Zaki NaserullahAlomran Scientific Chair for Hematological Diseases, King Faisal University, King Faisal University, King Fahd Hospital, Hafof, Al-Ahsa, Kingdom of Saudi Arabia.
Ahmed SulimanAlomran Scientific Chair, King Faisal University, King Fahd Hospital, Hafof, Al-Ahsa, Kingdom of Saudi Arabia.
P K PatraDepartment of Biochemistry, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India.
Jacqueline N MiltonDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Lindsay A FarrerDepartment of Medicine, Boston University School of Medicine, Boston, Massachusetts.
David H K ChuiDepartment of Medicine, Boston University School of Medicine, Boston, Massachusetts.
Amein K Al-AliCenter for Research & Medical Consultation, University of Dammam, Dammam, Saudi Arabia.
Paola SebastianiDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Martin H SteinbergDepartment of Medicine, Boston University School of Medicine, Boston, Massachusetts.

Funding

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cellsU01HL107443 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHUI, DAVID H K, MOSTOSLAVSKY, GUSTAVO · 2011 to 2015
$8.3M
Genetic Modulation of Sickle Cell DiseaseR01HL068970 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEINBERG, MARTIN H. · 2001 to 2010
$7.0M
Genome-Wide Association Studies in Sickle Cell Anemia and in CentenariansR01HL087681 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEINBERG, MARTIN H. · 2007 to 2010
$6.0M
RESEARCH TRAINING IN BLOOD DISEASES AND RESOURCEST32HL007501 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LERNER, ADAM, STEINBERG, MARTIN H. · 1985 to 2018
$5.4M
Interdisciplinary Training for BiostatisticiansT32GM074905 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WHITE, LAURA FORSBERG · 2005 to 2019
$3.0M
Genetic Diversity of Sickle Cell AnemiaRC2HL101212 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEINBERG, MARTIN H. · 2009 to 2010
$3.0M
NHLBI NIH HHS R01 HL068970NHLBI NIH HHS R01 HL087681NHLBI NIH HHS RC2 HL101212NHLBI NIH HHS T32 HL007501NHLBI NIH HHS U01 HL107443NIGMS NIH HHS T32 GM074905
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdolescentAdultAnemia, Sickle CellArabsFetal Hemoglobingamma-GlobinsGenome-Wide Association StudyHaplotypesHomozygoteHumansPolymorphism, Single NucleotideYoung AdultFetal Hemoglobingamma-Globins

Identifiers

PMID27185208
PMCPMC4874527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.