ArticleBMC biology2016
Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans.
Article in BMC biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Molecular Dynamics of Trogocytosis and Other Contact-Dependent Cell Trafficking Mechanisms in Tumor Pathogenesis.Cancers · 2025Review
- Cell death by phagocytosis.Nature reviews. Immunology · 2024Review
- mScarlet and split fluorophore mScarlet resources for plasmid-based CRISPR/Cas9 knock-in inmicroPublication biology · 2023Article
- LPS-stimulated microglial cells promote ganglion cell death in organotypic cultures of quail embryo retina.Frontiers in cellular neuroscience · 2023Article
- Regulation of Developmental Cell Death in the Animal Kingdom: A Critical Analysis of Epigenetic versus Genetic Factors.International journal of molecular sciences · 2022Review
- Review
- Cell death in animal development.Development (Cambridge, England) · 2020Review
- Activity-Dependent Regulation of the Proapoptotic BH3-Only GeneG3 (Bethesda, Md.) · 2019Article
- ALG-2/AGO-DependentGenetics · 2019Article
- Entosis Controls a Developmental Cell Clearance in C. elegans.Cell reports · 2019Article
- Dynein links engulfment and execution of apoptosis via CED-4/Apaf1 in C. elegans.Cell death & disease · 2018Article
- Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia.Cell reports · 2018Article
- Programmed cell removal by calreticulin in tissue homeostasis and cancer.Nature communications · 2018Article
- Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis.PLoS genetics · 2018Article
- Neuronal Cell Death.Physiological reviews · 2018Review
- There are only four basic modes of cell death, although there are many ad-hoc variants adapted to different situations.Cell & bioscience · 2018Review
- 6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33.PLoS genetics · 2018Article
- Article
- spict, a cyst cell-specific gene, regulates starvation-induced spermatogonial cell death in the Drosophila testis.Scientific reports · 2017Article
- Scrambled Eggs: Apoptotic Cell Clearance by Non-Professional Phagocytes in theFrontiers in immunology · 2017Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundProgrammed cell deaths in the nematode Caenorhabditis elegans are generally considered suicides. Dying cells are engulfed by neighboring cells in a process of phagocytosis. To better understand the interaction between the engulfment and death processes, we analyzed B.al/rapaav cell death, which has been previously described as engulfment-dependent and hence as a possible murder.
resultsWe found that B.al/rapaav is resistant to caspase-pathway activation: the caspase-mediated suicide pathway initiates the cell-death process but is insufficient to cause B.al/rapaav death without the subsequent assistance of engulfment. When the engulfing cell P12.pa is absent, other typically non-phagocytic cells can display cryptic engulfment potential and facilitate this death.
conclusionsWe term this death an "assisted suicide" and propose that assisted suicides likely occur in other organisms. The study of assisted suicides might provide insight into non-cell autonomous influences on cell death. Understanding the mechanism that causes B.al/rapaav to be resistant to activation of the caspase pathway might reveal the basis of differences in the sensitivity to apoptotic stimuli of tumor and normal cells, a key issue in the field of cancer therapeutics.
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