Evidence map›Paper›PMID 27185022›Full record

ReviewCirculation2016

Brain in Congenital Heart Disease Across the Lifespan: The Cumulative Burden of Injury.

Ariane Marelli, Steven P Miller, Bradley Scott Marino, Angela L Jefferson, Jane W Newburger

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Circulation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed, 6 pooled it
20.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 6 syntheses or guidelines pooled it, 356 citations in OpenAlex.

  1. Pooled it
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  12. Trigger Criteria for Advance-Care Planning in ACHD: The Time Is Now.CJC pediatric and congenital heart disease · 2026
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99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ariane MarelliFrom Division of Cardiology, McGill University Health Centre and Department of Medicine, McGill University, Montreal, QC, Canada (A.M.); The Department of Paediatrics, Hospital for Sick Children and the University of Toronto, ON, Canada (S.P.M.); Divisions of Cardiology and Critical Care Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Department of Pediatrics, Northwestern University Feinberg School of Medicine, IL (B.S.M.); Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN (A.L.J.); and Department of Cardiology, Children's Hospital Boston and Department of Pediatrics, Harvard Medical School, MA (J.W.N.). ariane.marelli@mcgill.ca.
Steven P MillerFrom Division of Cardiology, McGill University Health Centre and Department of Medicine, McGill University, Montreal, QC, Canada (A.M.); The Department of Paediatrics, Hospital for Sick Children and the University of Toronto, ON, Canada (S.P.M.); Divisions of Cardiology and Critical Care Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Department of Pediatrics, Northwestern University Feinberg School of Medicine, IL (B.S.M.); Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN (A.L.J.); and Department of Cardiology, Children's Hospital Boston and Department of Pediatrics, Harvard Medical School, MA (J.W.N.).
Bradley Scott MarinoFrom Division of Cardiology, McGill University Health Centre and Department of Medicine, McGill University, Montreal, QC, Canada (A.M.); The Department of Paediatrics, Hospital for Sick Children and the University of Toronto, ON, Canada (S.P.M.); Divisions of Cardiology and Critical Care Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Department of Pediatrics, Northwestern University Feinberg School of Medicine, IL (B.S.M.); Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN (A.L.J.); and Department of Cardiology, Children's Hospital Boston and Department of Pediatrics, Harvard Medical School, MA (J.W.N.).
Angela L JeffersonFrom Division of Cardiology, McGill University Health Centre and Department of Medicine, McGill University, Montreal, QC, Canada (A.M.); The Department of Paediatrics, Hospital for Sick Children and the University of Toronto, ON, Canada (S.P.M.); Divisions of Cardiology and Critical Care Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Department of Pediatrics, Northwestern University Feinberg School of Medicine, IL (B.S.M.); Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN (A.L.J.); and Department of Cardiology, Children's Hospital Boston and Department of Pediatrics, Harvard Medical School, MA (J.W.N.).
Jane W NewburgerFrom Division of Cardiology, McGill University Health Centre and Department of Medicine, McGill University, Montreal, QC, Canada (A.M.); The Department of Paediatrics, Hospital for Sick Children and the University of Toronto, ON, Canada (S.P.M.); Divisions of Cardiology and Critical Care Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago and Department of Pediatrics, Northwestern University Feinberg School of Medicine, IL (B.S.M.); Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN (A.L.J.); and Department of Cardiology, Children's Hospital Boston and Department of Pediatrics, Harvard Medical School, MA (J.W.N.).
Hospital for Sick Children · CASickKids Foundation · CAMcGill University Health Centre · CA

Funding

Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SAHIN, MUSTAFA · 2016 to 2020
$5.2M
Risk factors and prevention targets for abnormal cognitive agingK24AG046373 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2014 to 2023
$1.7M
NIA NIH HHS K24 AG046373NICHD NIH HHS U54 HD083211NICHD NIH HHS U54 HD090255
6 · The paper itself

Abstract

The number of patients surviving with congenital heart disease (CHD) has soared over the last 3 decades. Adults constitute the fastest-growing segment of the CHD population, now outnumbering children. Research to date on the heart-brain intersection in this population has been focused largely on neurodevelopmental outcomes in childhood and adolescence. Mutations in genes that are highly expressed in heart and brain may cause cerebral dysgenesis. Together with altered cerebral perfusion in utero, these factors are associated with abnormalities of brain structure and brain immaturity in a significant portion of neonates with critical CHD even before they undergo cardiac surgery. In infancy and childhood, the brain may be affected by risk factors related to heart disease itself or to its interventional treatments. As children with CHD become adults, they increasingly develop heart failure, atrial fibrillation, hypertension, diabetes mellitus, and coronary disease. These acquired cardiovascular comorbidities can be expected to have effects similar to those in the general population on cerebral blood flow, brain volumes, and dementia. In both children and adults, cardiovascular disease may have adverse effects on achievement, executive function, memory, language, social interactions, and quality of life. Against the backdrop of shifting demographics, risk factors for brain injury in the CHD population are cumulative and synergistic. As neurodevelopmental sequelae in children with CHD evolve to cognitive decline or dementia during adulthood, a growing population of CHD can be expected to require support services. We highlight evidence gaps and future research directions.

Indexed as

Cost of IllnessBrainBrain InjuriesChildChild DevelopmentHeart Defects, CongenitalHumansLongevityRisk Factorscongenital abnormalitiesheart diseases

Identifiers

PMID27185022
PMCPMC5519142
OpenAlexW2408520533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.