ArticleAnnals of family medicine2016
Symptomatic and Asymptomatic Colon Cancer Recurrence: A Multicenter Cohort Study.
Article in Annals of family medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 8 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Comparing Open, Laparoscopic and Robotic Liver Resection for Metastatic Colorectal Cancer-A Systematic Review and Network Meta-Analysis.Journal of surgical oncology · 2025Pooled it
- Delayed Versus Immediate Start of Chemotherapy in Asymptomatic Patients With Advanced Cancer: A Meta-Analysis.The oncologist · 2023Pooled it
- The incidence of malignancy in the residual rectum of IBD patients after colectomy: a systematic review and meta-analysis.Techniques in coloproctology · 2023Pooled it
- A systematic review of the effectiveness of patient-initiated follow-up after cancer.Cancer medicine · 2023Pooled it
- Systematic review of patients' and healthcare professionals' views on patient-initiated follow-up in treated cancer patients.Cancer medicine · 2023Pooled it
- Detection of asymptomatic recurrence following curative surgery improves survival in patients with gastric cancer: A systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Diagnostic accuracy of follow-up tests for detecting colorectal cancer recurrences in primary care: A systematic review and meta-analysis.European journal of cancer care · 2021Pooled it
- Pooled it
- Trial
- Organizing substitution of oncological follow-up to primary care: perspectives from secondary care providers.Journal of cancer survivorship : research and practice · 2026Article
- Long-Term Outcomes and Conditional Recurrence-Free Survival in Stage II Colon Cancer: The Impact of Surveillance and Recurrence Detection Strategies.Journal of clinical medicine · 2026Article
- Detecting cancer recurrence in general practice: a Danish national cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Review
- Modeling Microbiome Modulation of Tumor Metabolic Networks to Predict Synergistic Therapies.bioRxiv : the preprint server for biology · 2026Article
- Clinical assessment of recurrent cancer: a Danish cohort study in general practice.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Postoperative Abdominal Infectious Complications Promote Colon Cancer Metastasis by Inducing MDSCs to Release Neutrophil Extracellular Traps.Journal of inflammation research · 2026Article
- Tumor cell-intrinsic PD-1 regulates chemotherapy resistance in colorectal cancer cells by activating downstream MAPK signaling.BJC reports · 2025Article
- Design and Evaluation of Dual-Targeted Radionuclide Therapeutics for NTS1 with Improved Tumor Retention through Endolysosomal Trapping.ACS omega · 2025Article
- Mechanisms and Strategies to Overcome Drug Resistance in Colorectal Cancer.International journal of molecular sciences · 2025Review
- High leafy and root vegetables and high rice dietary patterns were associated with primary and secondary bile acid levels in the feces.Scientific reports · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFollow-up after colorectal cancer treatment with curative intent aims to detect recurrences and metachronous tumors in a timely manner. The objective of this study is to assess how recurrent disease presents and is diagnosed within scheduled follow-up according to the national guideline for the Netherlands.
methodsIn a retrospective study of consecutive patients with colorectal cancer who were treated in 2 hospitals in the Netherlands, we identified patients with colon cancer who underwent surgery with curative intent between January 2007 and December 2012. Patients who developed recurrent disease were included for further analyses.
resultsFrom a total of 446 patients who were been treated for colon carcinoma with curative intent, 74 developed recurrent disease (17%). In 43 of those patients (58%), recurrent disease was detected during a scheduled follow-up visit, with 41 (95%) being asymptomatic. Tumor marker testing, imaging, and colonoscopy identified all of these recurrences. In the remaining 31 patients with recurrent disease (42%), recurrence was found during non-scheduled interval visits; 26 (84%) of these patients were symptomatic. The most prevalent symptoms were abdominal pain, altered defecation, and weight loss. Patients with asymptomatic recurrences had a significantly higher overall survival compared with patients with symptomatic recurrences.
conclusionsIn this cohort, 42% of the recurrences after initial curative treatment for colon cancer were found during non-scheduled interval visits, mainly based on symptoms. Primary care physicians who take care of patients whose colon cancer might recur should be aware of the relatively high rate of symptomatic recurrences and of typical presenting symptoms.
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