ArticleJournal of clinical laboratory analysis2016
Ascitic Calprotectin is a Novel and Accurate Marker for Spontaneous Bacterial Peritonitis.
Article in Journal of clinical laboratory analysis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Preanalytical study concerning the influence of tube type and centrifugation conditions on the concentration of calprotectin in ascites.Biochemia medica · 2026Article
- Increased Mortality with Intermediate Ascitic Polymorphonuclear Cell Counts Amongst Patients with Cirrhosis: Time to Redefine the Care Approach.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Exploring the next frontier in diagnosing spontaneous bacterial peritonitis.World journal of hepatology · 2025Article
- Ascites fluid calprotectin level is highly accurate in diagnosing spontaneous bacterial peritonitis: a preliminary proof of concept prospective study.Clinical and experimental medicine · 2024Article
- Fecal calprotectin in cirrhosis-Does "ESR" of the intestine measure the liver dysfunction too?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- Article
- Evaluation of DiaSorin LiaisonAdvances in laboratory medicine · 2023Article
- The synovial fluid calprotectin lateral flow test for the diagnosis of chronic prosthetic joint infection in failed primary and revision total hip and knee arthroplasty.International orthopaedics · 2023Article
- An evaluation of ascitic calprotectin for diagnosis of ascitic fluid infection in children with cirrhosis.BMC pediatrics · 2022Article
- Diagnosing Periprosthetic Joint Infection: a Scoping Review.Current reviews in musculoskeletal medicine · 2022Article
- Ascitic calprotectin and lactoferrin for detection of spontaneous bacterial peritonitis: a systematic review and meta-analysis.Translational gastroenterology and hepatology · 2022Article
- Influence of Xuebijing injection combined with cefoperazone sodium and sulbactam sodium in treating hepatitis B-induced liver cirrhosis complicated by spontaneous bacterial peritonitis: TNF-α, IL-18, IL-6, and hepatic function.American journal of translational research · 2021Article
- Ascitic Calprotectin as an early predictor of hepatocellular carcinoma in patients with cirrhotic ascites.Journal of cancer research and clinical oncology · 2020Article
- The value of calprotectin in synovial fluid for the diagnosis of chronic prosthetic joint infection.Bone & joint research · 2020Article
- Laboratory testing of extravascular body fluids: National recommendations on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine. Part I - Serous fluids.Biochemia medica · 2020Review
- Evaluation of a fluorescent immunochromatography test for fecal calprotectin.Journal of clinical laboratory analysis · 2020Article
- Article
- A novel turbidimetric immunoassay for fecal calprotectin optimized for routine chemistry analyzers.Journal of clinical laboratory analysis · 2017Article
- Comment on 'Ascitic Fluid Analysis in the Differential Diagnosis of Ascites: Focus on Cirrhotic Ascites'.Journal of clinical and translational hepatology · 2017Article
- Spontaneous peritonitis in critically ill cirrhotic patients: a diagnostic algorithm for clinicians and future perspectives.Therapeutics and clinical risk management · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpontaneous bacterial peritonitis (SBP) is a known complication of advanced cirrhosis and presents a high mortality rate. A polymorphonuclear (PMN) cell count >250/μl in the ascitic fluid is the current gold standard for diagnosing SBP.
aimWe evaluated the accuracy of a point-of-care test (POCT) for ascitic calprotectin in diagnosing patients with SBP.
methodsEighty-eight patients admitted with decompensation of liver cirrhosis were studied including 41 patients (46.6%) with SBP. Ascitic calprotectin was measured using a quantitative POCT developed by Bühlmann
resultsCalprotectin levels correlated with PMN cell count and other inflammatory markers and were significantly higher in patients with SBP. An optimal cutoff of calprotectin above 1.57 μg/ml presented high sensitivity (87.8%), specificity (97.9%), and positive (97.3%) and negative (90.2%) predictive values for diagnosing SBP. Using calprotectin selectively in patients with a serum albumin-ascites gradient above 11 g/l further increased the sensitivity and negative predictive values of the test.
conclusionAscitic calprotectin appears to be a reliable method for diagnosing SBP in patients with liver cirrhosis. It may present an alternative to other conventional diagnostic methods.
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