ArticleBMC developmental biology2016
β-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis.
Article in BMC developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
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- Ectopic Posterior Pituitary and Its Associations with Extrapituitary Intracranial Anomalies.The Indian journal of radiology & imaging · 2024Article
- Evolutionary origin of the chordate nervous system revealed by amphioxus developmental trajectories.Nature ecology & evolution · 2024Article
- Pituitary stem cells: past, present and future perspectives.Nature reviews. Endocrinology · 2024Review
- Neural crest and sons: role of neural crest cells and Schwann cell precursors in development and gland embryogenesis.Frontiers in cell and developmental biology · 2024Review
- Missing pieces of the pituitary puzzle: participation of extra-adenohypophyseal placode-lineage cells in the adult pituitary gland.Cell and tissue research · 2023Review
- SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context.Science advances · 2023Article
- An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development.PloS one · 2023Article
- Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair.Bone research · 2022Review
- New insights into the role and origin of pituitary S100β-positive cells.Cell and tissue research · 2021Review
- On the road again: Establishment and maintenance of stemness in the neural crest from embryo to adulthood.Stem cells (Dayton, Ohio) · 2021Review
- Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.JCI insight · 2020Article
- Pituitary Gangliocytoma Producing TSH and TRH: A Review of "Gangliocytomas of the Sellar Region".The Journal of clinical endocrinology and metabolism · 2020Review
- Wnt1 silencing enhances neurotoxicity induced by paraquat and maneb in SH-SY5Y cells.Experimental and therapeutic medicine · 2019Article
- Genomic approaches to identify hybrids and estimate admixture times in European wildcat populations.Scientific reports · 2019Article
- Using mouse transgenic and human stem cell technologies to model genetic mutations associated with schizophrenia and autism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways.Molecular and cellular endocrinology · 2017Review
- Gene tracing analysis reveals the contribution of neural crest-derived cells in pituitary development.Journal of anatomy · 2017Article
- Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases.Stem cells international · 2017Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe pituitary gland is a highly vascularized tissue that requires coordinated interactions between the neural ectoderm, oral ectoderm, and head mesenchyme during development for proper physiological function. The interactions between the neural ectoderm and oral ectoderm, especially the role of the pituitary organizer in shaping the pituitary precursor, Rathke's pouch, are well described. However, less is known about the role of head mesenchyme in pituitary organogenesis. The head mesenchyme is derived from definitive mesoderm and neural crest, but the relative contributions of these tissues to the mesenchyme adjacent to the pituitary are not known.
resultsWe carried out lineage tracing experiments using two neural crest-specific mouse cre lines, Wnt1-cre and P0-cre, and determined that the head mesenchyme rostral to the pituitary gland is neural crest derived. To assess the role of the neural crest in pituitary development we ablated it, using Wnt1-cre to delete Ctnnb1 (β-catenin), which is required for neural crest development. The Wnt1-cre is active in the neural ectoderm, principally in the mesencephalon, but also in the posterior diencephalon. Loss of β-catenin in this domain causes a rostral shift in the ventral diencephalon, including the pituitary organizer, resulting in pituitary dysmorphology. The neural crest deficient embryos have abnormally dilated pituitary vasculature due to a loss of neural crest derived pericytes.
conclusionsβ-catenin in the Wnt1 expression domain, including the neural crest, plays a critical role in regulation of pituitary gland growth, development, and vascularization.
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