Evidence map›Paper›PMID 27184890›Full record

ArticleGenome biology2016

Response to "Variable directionality of gene expression changes across generations does not constitute negative evidence of epigenetic inheritance" Sharma, A. Environmental Epigenetics, 2015, 1-5.

Piroska E Szabó

Abstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The sources of adaptive variation.Proceedings. Biological sciences · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Piroska E SzabóVan Andel Research Institute, Center for Epigenetics, 333 Bostwick Ave, Grand Rapids, MI, 49503, USA. piroska.szabo@vai.org.

Funding

Mechanisms of Genomic ImprintingR01GM064378 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI SZABÓ, PIROSKA EDIT · 2002 to 2015
$4.3M
Epigenetic effects if endocrine disruptors in fetal germ cellsR01ES015185 · NIEHS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SZABÓ, PIROSKA EDIT · 2006 to 2010
$2.0M
NIEHS NIH HHS R01 ES015185NIEHS NIH HHS R01ES015185NIGMS NIH HHS R01 GM064378NIGMS NIH HHS R01GM064378
6 · The paper itself

Abstract

Abhay Sharma brings two arguments in favor of transgenerational epigenetic inheritance (TGEI) in mammals when criticizing our work. He uses probability calculations and finds that the probability of obtaining the number of common changes in the in utero-exposed prospermatogonia and the same cells in the next generation is significant in our study. He also compares our results to other published datasets and concludes that the probability for the observed overlap between independent studies is significant. We disagree with both arguments of Sharma and show here that his meta-analysis and statistical calculations are not correct.

Indexed as

AnimalsCellular ReprogrammingDNA MethylationEpigenesis, GeneticFemaleGenomic ImprintingMalePregnancy

Identifiers

PMID27184890
PMCPMC4868108

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.