Evidence map›Paper›PMID 27184805›Full record

ArticleJournal of cardiovascular translational research2016

Cardiac Strain in a Swine Model of Regional Hibernating Myocardium: Effects of CoQ10 on Contractile Reserve Following Bypass Surgery.

Laura Hocum Stone, Tammy A Butterick, Cayla Duffy, Corey Swingen, Herbert B Ward, Rosemary F Kelly, Edward O McFalls

Abstract read
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In one paragraph

Article in Journal of cardiovascular translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Laura Hocum StoneDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Tammy A ButterickResearch Minneapolis VAHCS, Minneapolis, MN, 55417, USA.
Cayla DuffyResearch Minneapolis VAHCS, Minneapolis, MN, 55417, USA.
Corey SwingenDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Herbert B WardDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Rosemary F KellyDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Edward O McFallsDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA. mcfal001@umn.edu.
University of Minnesota · USMinneapolis VA Health Care System · US

Funding

Surgical Revascularization's Impact on Mitochondria in Hibernating MyocardiumI01BX000760 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI MCFALLS, EDWARD O. · 2011 to 2017
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BLRD VA I01 BX000760
6 · The paper itself

Abstract

There is conflicting clinical evidence whether administration of coenzyme Q10 (CoQ10) improves function following coronary artery bypass graft surgery (CABG). Using a swine model of hibernating myocardium, we tested whether daily CoQ10 would improve contractile function by MRI at 4-week post-CABG. Twelve pigs underwent a thoracotomy and had a constrictor placed on the left anterior descending (LAD). At 12 weeks, they underwent off-pump bypass and received daily dietary supplements of either CoQ10 (10 mg/kg/day) or placebo. At 4-week post-CABG, circumferential strain measurements in the hibernating LAD region from placebo and CoQ10 groups were not different and increased to a similar extent with dobutamine (-14.7 ± 0.6 versus -14.8 ± 0.1, respectively (NS)). Post-sacrifice, oxidant stress markers were obtained in the mitochondrial isolates and protein carbonyl in the placebo, and CoQ10 groups were 6.14 ± 0.36 and 5.05 ± 0.32 nmol/mg, respectively (NS). In summary, CoQ10 did not improve contractile reserve or reduce oxidant stress at 4-week post-CABG.

Indexed as

Coronary Artery Bypass, Off-PumpAnimalsBiomarkersBiomechanical PhenomenaCardiotonic AgentsCoronary Artery DiseaseDisease Models, AnimalFemaleMagnetic Resonance ImagingMitochondria, HeartMyocardial ContractionMyocardial StunningMyocardiumOxidative StressProtein CarbonylationRecovery of FunctionBiomarkersCardiotonic Agentscoenzyme Q10UbiquinoneBypass surgeryChronically ischemic myocardiumContractile reserveHibernating myocardiumMitochondriaMRIOxidant stress

Identifiers

PMID27184805
OpenAlexW2406328847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.