ArticleNano letters2016
Shape and Interhelical Spacing of DNA Origami Nanostructures Studied by Small-Angle X-ray Scattering.
Article in Nano letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Characterizing the structure of 3D DNA origami in a transmission electron microscope.RSC advances · 2026Article
- Hybridization on DNA-Coated Ultrasmall Gold Nanoparticles (2 nm).Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- DNA origami signal amplification in lateral flow immunoassays.Nature communications · 2025Article
- Revolutionizing tumor diagnosis and treatment: the promise of DNA nanotechnology.Frontiers in immunology · 2025Review
- Article
- Dominant Analytical Techniques in DNA Nanotechnology for Various Applications.Analytical chemistry · 2024Article
- Programming the morphology of DNA origami crystals by magnesium ion strength.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Lyophilization Reduces Aggregation of Three-Dimensional DNA Origami at High Concentrations.ACS omega · 2023Article
- A label-free light-scattering method to resolve assembly and disassembly of DNA nanostructures.Biophysical journal · 2022Article
- Article
- Far-Field Electrostatic Signatures of Macromolecular 3D Conformation.Nano letters · 2022Article
- In situ small-angle X-ray scattering reveals strong condensation of DNA origami during silicification.Nature communications · 2022Article
- Leakless end-to-end transport of small molecules through micron-length DNA nanochannels.Science advances · 2022Article
- The biological applications of DNA nanomaterials: current challenges and future directions.Signal transduction and targeted therapy · 2021Review
- DNA Origami Meets Bottom-Up Nanopatterning.ACS nano · 2021Review
- A Versatile DNA Origami-Based Plasmonic Nanoantenna for Label-Free Single-Molecule Surface-Enhanced Raman Spectroscopy.ACS nano · 2021Article
- Site-specific covalent labeling of large RNAs with nanoparticles empowered by expanded genetic alphabet transcription.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- DNA Origami Nano-Sheets and Nano-Rods Alter the Orientational Order in a Lyotropic Chromonic Liquid Crystal.Nanomaterials (Basel, Switzerland) · 2020Article
- Article
- Effect of Staple Age on DNA Origami Nanostructure Assembly and Stability.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Scaffolded DNA origami nanostructures enable the self-assembly of arbitrarily shaped objects with unprecedented accuracy. Yet, varying physiological conditions are prone to induce slight structural changes in the nanoscale architecture. Here, we report on high precision measurements of overall shape and interhelical distance of three prototypic DNA origami structures in solution using synchrotron small-angle X-ray scattering. Sheet-, brick-, and cylinder-shaped DNA constructs were assembled and the shape factors determined with angstrom resolution from fits to the scattering profiles. With decreasing MgCl2 concentration electrostatic swelling of both shape cross section and interhelical DNA spacing of the DNA origami structures is observed. The structures tolerate up to 10% interhelical expansion before they disintegrate. In contrast, with increasing temperature, the cylinder-shaped structures show no thermal expansion in a wide temperature window before they abruptly melt above 50 °C. Details on molecular structure of DNA origami can also be obtained using in-house X-ray scattering equipment and, hence, allow for routine folding and stability testing of DNA-based agents that are designed to operate under varying salt conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.