ArticleConnective tissue research2016
Murine supraspinatus tendon injury model to identify the cellular origins of rotator cuff healing.
Article in Connective tissue research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- The subacromial bursa in rotator cuff injury: from pathological contributor to regenerative resource?Frontiers in bioengineering and biotechnology · 2026Review
- Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how).Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Review
- PIEZO1 is downregulated in glenohumeral chondrocytes in early cuff tear arthropathy following a massive rotator cuff tear in a mouse model.Frontiers in bioengineering and biotechnology · 2023Article
- Tendon progenitor cells as biological augmentation improve functional gait and reduce scar formation after rotator cuff repair.Journal of shoulder and elbow surgery · 2022Article
- The role of loading in murine models of rotator cuff disease.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Review
- Augmenting Suture Tape Used in Rotator Cuff Surgery With Magnesium Increases in Vitro Cellular Adhesion of Human Subacromial Bursal Tissue.Arthroscopy, sports medicine, and rehabilitation · 2021Article
- Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon.Cell death & disease · 2021Article
- Cell lineage tracing and functional assessment of supraspinatus tendon healing in an acute repair murine model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Effects of tamoxifen on tendon homeostasis and healing: Considerations for the use of tamoxifen-inducible mouse models.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- The Effect of Insulin and Insulin-like Growth Factor 1 (IGF-1) on Cellular Proliferation and Migration of Human Subacromial Bursa Tissue.Arthroscopy, sports medicine, and rehabilitation · 2021Article
- Development and maintenance of tendons and ligaments.Development (Cambridge, England) · 2021Review
- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life.Advances in experimental medicine and biology · 2021Review
- Dielectrophoresis as a tool for electrophysiological characterization of stem cells.Biophysics reviews · 2020Review
- Amplifying Bone Marrow Progenitors Expressing α-Smooth Muscle Actin Produce Zonal Insertion Sites During Tendon-to-Bone Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Tendon and Ligament Healing and Current Approaches to Tendon and Ligament Regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- MicroRNA-29a Mitigates Subacromial Bursa Fibrosis in Rotator Cuff Lesion with Shoulder Stiffness.International journal of molecular sciences · 2019Article
- Tendon stem progenitor cells: Understanding the biology to inform therapeutic strategies for tendon repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Review
- Biologics and stem cell-based therapies for rotator cuff repair.Annals of the New York Academy of Sciences · 2019Review
- Models of tendon development and injury.BMC biomedical engineering · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Purpose of this study: To elucidate the origin of cell populations that contribute to rotator cuff healing, we developed a mouse surgical model where a full-thickness, central detachment is created in the supraspinatus. MATERIALS AND
methodsThree different inducible Cre transgenic mice with Ai9-tdTomato reporter expression (PRG4-9, αSMA-9, and AGC-9) were used to label different cell populations in the shoulder. The defect was created surgically in the supraspinatus. The mice were injected with tamoxifen at surgery to label the cells and sacrificed at 1, 2, and 5 weeks postoperatively. Frozen sections were fluorescently imaged then stained with Toluidine Blue and re-imaged.
resultsThree notable changes were apparent postoperatively. (1) A long thin layer of tissue formed on the bursal side overlying the supraspinatus tendon. (2) The tendon proximal to the defect initially became hypercellular and disorganized. (3) The distal stump at the insertion underwent minimal remodeling. In the uninjured shoulder, tdTomato expression was seen in the tendon midsubstance and paratenon cell on the bursal side in PRG4-9, in paratenon, blood vessels, and periosteum of acromion in SMA-9, and in articular cartilage, unmineralized fibrocartilage of supraspinatus enthesis, and acromioclavicular joint in AGC-9 mice. In the injured PRG4-9 and SMA-9 mice, the healing tissues contained an abundant number of tdTomato+ cells, while minimal contribution of tdTomato+ cells was seen in AGC-9 mice.
conclusionsThe study supports the importance of the bursal side of the tendon to rotator cuff healing and PRG4 and αSMA may be markers for these progenitor cells.
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