ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2016
Neuroimaging the Effectiveness of Substance Use Disorder Treatments.
Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- N-acetylcysteine as a treatment for substance use cravings: A meta-analysis.Addiction biology · 2024Pooled it
- The Use of Functional Magnetic Resonance Imaging to Test Pharmacotherapies for Alcohol Use Disorder: A Systematic Review.Alcoholism, clinical and experimental research · 2019Pooled it
- The difference in the effect of methadone and protracted abstinence on the coupling among key large-scale brain networks of individuals with heroin use disorder: A resting-state fMRI study.Psychological medicine · 2025Article
- N-acetylcysteine as a treatment for substance use cravings: A meta-analysis.medRxiv : the preprint server for health sciences · 2024Article
- Article
- Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders.Dialogues in clinical neuroscience · 2023Review
- Effects of bupropion and SSRI antidepressants on leg movement activity and chin muscle tone during sleep in adolescents.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Noninvasive Vagal Nerve Stimulation for Opioid Use Disorder.Annals of depression and anxiety · 2023Article
- The Interplay of Environmental Exposures and Mental Health: Setting an Agenda.Environmental health perspectives · 2022Review
- Altered Global Signal Topography in Alcohol Use Disorders.Frontiers in aging neuroscience · 2022Article
- Noninvasive Brain Stimulation Rescues Cocaine-Induced Prefrontal Hypoactivity and Restores Flexible Behavior.Biological psychiatry · 2021Article
- Conscious and unconscious brain responses to food and cocaine cues.Brain imaging and behavior · 2021Article
- Gene coexpression patterns predict opiate-induced brain-state transitions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Alcohol Use Disorder Interventions Targeting Brain Sites for Both Conditioned Reward and Delayed Gratification.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Design of a randomized controlled trial examining the efficacy of oxytocin to enhance alcohol behavioral couple therapy.Contemporary clinical trials · 2019Article
- Alterations in resting-state functional connectivity in substance use disorders and treatment implications.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
- Preliminary development of a neuroimaging paradigm to examine neural correlates of relationship conflict.Psychiatry research. Neuroimaging · 2019Article
- Cerebral Biochemical Effect of Pregabalin in Patients with Painful Diabetic Neuropathy: A Randomized Controlled Trial.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2018Article
- Goal Directed and Self-Control Systems in Bulimia Nervosa: An fMRI Study.EBioMedicine · 2018Article
- Cortico-Amygdala-Striatal Activation by Modafinil/Flecainide Combination.The international journal of neuropsychopharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Neuroimaging techniques to measure the function and biochemistry of the human brain such as positron emission tomography (PET), proton magnetic resonance spectroscopy ((1)H MRS), and functional magnetic resonance imaging (fMRI), are powerful tools for assessing neurobiological mechanisms underlying the response to treatments in substance use disorders. Here, we review the neuroimaging literature on pharmacological and behavioral treatment in substance use disorder. We focus on neural effects of medications that reduce craving (e.g., naltrexone, bupropion hydrochloride, baclofen, methadone, varenicline) and that improve cognitive control (e.g., modafinil, N-acetylcysteine), of behavioral treatments for substance use disorders (e.g., cognitive bias modification training, virtual reality, motivational interventions) and neuromodulatory interventions such as neurofeedback and transcranial magnetic stimulation. A consistent finding for the effectiveness of therapeutic interventions identifies the improvement of executive control networks and the dampening of limbic activation, highlighting their values as targets for therapeutic interventions in substance use disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.