ArticleMolecular psychiatry2017
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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26citing papers in PubMed, 2 pooled it
15.6field-weighted citation impact, top 1% of its field
What it found
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Epigenetic alterations in patients with anorexia nervosa-a systematic review.Molecular psychiatry · 2024Pooled it
- Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa.The American journal of psychiatry · 2017Pooled it
- Anxiety-metabolism networks in human anorexia nervosa: Responses to caloric and non-caloric meals in the Networks Integrating Anxiety and Metabolism in Anorexia Nervosa (NAMA) randomized trial.The British journal of nutrition · 2026Trial
- Trial
- Sex-stratified insights into the genetics of brain volumes in late adulthood.Biology of sex differences · 2026Article
- Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation.Molecular psychiatry · 2025Article
- An evolutionary perspective on the genetics of anorexia nervosa.Translational psychiatry · 2025Article
- Temperament impact on eating disorder symptoms and habit formation: a novel model to inform treatment.Journal of eating disorders · 2024Review
- Disrupted longitudinal restoration of brain connectivity during weight normalization in severe anorexia nervosa.Translational psychiatry · 2023Article
- The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits.Nature reviews. Endocrinology · 2022Review
- PTBP2 - a gene with relevance for both Anorexia nervosa and body weight regulation.Translational psychiatry · 2022Article
- Gene variants in eating disorders. Focus on anorexia nervosa, bulimia nervosa, and binge-eating disorder.Journal of preventive medicine and hygiene · 2022Review
- Expression of CXCR4 on CD4Frontiers in psychiatry · 2022Article
- Review
- The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis.Nature communications · 2021Article
- Appetite- and weight-inducing and -inhibiting neuroendocrine factors in Prader-Willi syndrome, Bardet-Biedl syndrome and craniopharyngioma versus anorexia nervosa.Endocrine connections · 2021Review
- Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa.Scientific reports · 2021Article
- Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease.Human molecular genetics · 2020Article
- The Western diet: a blind spot of eating disorder research?-a narrative review and recommendations for treatment and research.Nutrition reviews · 2020Review
- Polygenic Score for Body Mass Index Is Associated with Disordered Eating in a General Population Cohort.Journal of clinical medicine · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
38 authors at 20 institutions in 7 countries.
A HinneyDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
M KesselmeierClinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.
S JallInstitute for Diabetes and Obesity, Helmholtz Diabetes Center & German Diabetes Center (DZD), Helmholtz Zentrum München, Neuherberg, Germany.
A-L VolckmarDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
M FöckerDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
J AntelDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
GCAN
WTCCC3
I M HeidDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
T W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
GIANT
S F A GrantDepartment of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA.
EGG
Y GuoThe Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-6549-8589
A W BergenBioRealm, LLC, Culver City, CA, USA.
W KayeDepartment of Psychiatry, University of California, San Diego, San Diego, CA, USA.
W BerrettiniDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
H HakonarsonThe Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Price Foundation Collaborative Group
Children’s Hospital of Philadelphia/Price Foundation
B Herpertz-DahlmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of the RWTH Aachen, Aachen, Germany.
M de ZwaanDepartment of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany.
W HerzogDepartment of Internal Medicine II, General Internal and Psychosomatic Medicine, University of Heidelberg, Heidelberg, Germany.
S EhrlichTranslational Developmental Neuroscience Section, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU-Dresden, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
S ZipfelDepartment of Psychosomatic Medicine and Psychotherapy, Medical University Hospital, Tübingen, Germany.
K M EgbertsDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
R AdanBrain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
M BrandysBrain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
A van ElburgBrain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
V Boraska PericaWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
C S FranklinWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
M H TschöpInstitute for Diabetes and Obesity, Helmholtz Diabetes Center & German Diabetes Center (DZD), Helmholtz Zentrum München, Neuherberg, Germany.
E ZegginiWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
C M BulikDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
D CollierSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
A ScheragClinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.ORCID 0000-0002-9406-4704
T D MüllerInstitute for Diabetes and Obesity, Helmholtz Diabetes Center & German Diabetes Center (DZD), Helmholtz Zentrum München, Neuherberg, Germany.
J HebebrandDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Essen University Hospital · DEKing's College London · GBWellcome Sanger Institute · GBUniversity of North Carolina at Chapel Hill · USHelmholtz Zentrum München · DEUniversity of Würzburg · DEUniversity Hospital Carl Gustav Carus · DEUniversity of Duisburg-Essen · DEHeidelberg University · DEJena University Hospital · DEBioRealm (United States) · USChildren's Hospital of Philadelphia · USUniversity of Pennsylvania · USUniversity Medical Center Utrecht · NLUniversity of Regensburg · DEAltrecht GGZ · NLMedizinische Hochschule Hannover · DERWTH Aachen University · DEUniversity of Tübingen · DEUniversity of California San Diego · US
Funding
Cell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1MGenome Wide Association Study for Childhood ObesityR01HD056465 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A · 2008 to 2024
$9.5MThe Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI SCHULTZ, ROBERT THOMAS · 2016 to 2020
$6.3MAging-related Traits and Disease Risk Factors in a Sardinian Population CohortZIAAG000675 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM · 2009 to 2021
$5.7MPostdoctoral Research Training in Eating DisordersT32MH076694 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2007 to 2016
$1.8MBIOMARKERS OF WEIGHT CHANGE IN ANOREXIA NERVOSAK01MH106675 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAKER, JESSICA H · 2016 to 2019
$651kShared Genetic and Environmental Risk Factors for Anorexia Nervosa and Obsessive-Compulsive Disorder in DenmarkK01MH109782 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YILMAZ, ZEYNEP · 2016 to 2019
$620kDevelopmental Psychopathology of Restrictive and Binge Eating in ChildhoodK01MH100435 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZERWAS, STEPHANIE CHRISTINE · 2013 to 2015
$488kMedical Research Council G1001799Medical Research Council MC_UU_12013/4Medical Research Council MR/K007017/1Medical Research Council MR/K013351/1Medical Research Council MR/M013138/1NICHD NIH HHS R01 HD056465NICHD NIH HHS U54 HD086984NIDDK NIH HHS R01 DK075787NIMH NIH HHS K01 MH100435NIMH NIH HHS K01 MH106675NIMH NIH HHS K01 MH109782NIMH NIH HHS T32 MH076694Wellcome Trust
Abstract
The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we performed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI-related loci was performed in the AN GWAMA. We detected significant associations (P-values <5 × 10
Indexed as
AllelesAnorexia NervosaBody Mass IndexBody WeightDatabases, GeneticFemaleGene FrequencyGenetic LociGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansLinkage DisequilibriumMaleObesityPolymorphism, Single Nucleotide
Identifiers
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