ReviewCurrent pain and headache reports2016
The Pathophysiology of Concussion.
Review in Current pain and headache reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Lifestyle modifications as therapy for medication refractory post-traumatic headache (PTHA) in the military population of Okinawa.The journal of headache and pain · 2018Trial
- Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players.iScience · 2026Article
- Relating brain function to cognitive-visuomotor integration performance in working-aged adults with persisting concussion symptoms.Frontiers in human neuroscience · 2026Article
- Article
- Brainwave Activity Localization, Mood Symptoms, and Balance Impairment in a Male South African Rugby Player With Persisting Symptoms After Concussion: A Case Report.Clinical case reports · 2025Article
- Reduced Cortical Excitability is Associated with Cognitive Symptoms in Concussed Adolescent Football Players.medRxiv : the preprint server for health sciences · 2024Article
- Exploring Symptom Overlaps: Post-COVID-19 Neurological Syndrome and Post-Concussion Syndrome in Athletes.Biomedicines · 2024Review
- An Assessment of Existing Sport-Related Concussion Guidelines in Ireland: The Need for a United Approach.Journal of functional morphology and kinesiology · 2024Article
- Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury.Zoological research · 2024Article
- The Convergent Validity of the SWAY Balance Application to Assess Postural Stability in Military Cadets Recovering from Concussion.International journal of sports physical therapy · 2024Article
- Precision Concussion Management: Approaches to Quantifying Head Injury Severity and Recovery.Brain sciences · 2023Review
- 'If in Doubt, Sit Them Out': How Long to Return to Elite Cycling Competition following a Sports-Related Concussion (SRC)?International journal of environmental research and public health · 2023Article
- Co-administration of Nanowired Oxiracetam and Neprilysin with Monoclonal Antibodies to Amyloid Beta Peptide and p-Tau Thwarted Exacerbation of Brain Pathology in Concussive Head Injury at Hot Environment.Advances in neurobiology · 2023Review
- Traumatic axonal injury: neuropathological features, postmortem diagnostic methods, and strategies.Forensic science, medicine, and pathology · 2022Review
- Corticospinal Excitability and Inhibition Are Not Different between Concussed Males and Females.Brain sciences · 2022Article
- Nano-PSO Administration Attenuates Cognitive and Neuronal Deficits Resulting from Traumatic Brain Injury.Molecules (Basel, Switzerland) · 2022Article
- Sex-related differences in visuomotor skill recovery following concussion in working-aged adults.BMC sports science, medicine & rehabilitation · 2022Article
- The University of Kansas Health System Outpatient Clinical Concussion Comprehensive Protocol: An Interdisciplinary Approach.Health services insights · 2022Article
- Teasing apart trauma: neural oscillations differentiate individual cases of mild traumatic brain injury from post-traumatic stress disorder even when symptoms overlap.Translational psychiatry · 2021Article
- Early Life Stress Exacerbates Outcome after Traumatic Brain Injury.Journal of neurotrauma · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Concussion is a significant issue in medicine and the media today. With growing interest on the long-term effects of sports participation, it is important to understand what occurs in the brain after an impact of any degree. While some of the basic pathophysiology has been elucidated, much is still unknown about what happens in the brain after traumatic brain injury, particularly with milder injuries where no damage can be seen at the structural level on standard neuroimaging. Understanding the chain of events from a cellular level using studies investigating more severe injuries can help to drive research efforts in understanding the symptomatology that is seen in the acute phase after concussion, as well as point to mechanisms that may underlie persistent post-concussive symptoms. This review discusses the basic neuropathology that occurs after traumatic brain injury at the cellular level. We also present the pathology of chronic traumatic encephalopathy and its similarities to other neurodegenerative diseases. We conclude with recent imaging and biomarker findings looking at changes that may occur after repeated subconcussive blows, which may help to guide efforts in understanding if cumulative subconcussive mechanical forces upon the brain are detrimental in the long term or if concussive symptoms mark the threshold for brain injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.