Evidence map›Paper›PMID 27184039›Full record

ArticleThe journal of prevention of Alzheimer's disease2016

Moderate, Regular Alcohol Consumption is Associated with Higher Cognitive Function in Older Community-Dwelling Adults.

E T Reas, G A Laughlin, D Kritz-Silverstein, E Barrett-Connor, L K McEvoy

Abstract read
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In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  12. Correlates of Memory and Executive Function in Middle-Aged and Older Adults in the CLSA: A Minority Stress Approach.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E T ReasDepartment of Radiology, University of California, San Diego, USA.
G A LaughlinDepartment of Family Medicine and Public Health, University of California, San Diego, USA.
D Kritz-SilversteinDepartment of Family Medicine and Public Health, University of California, San Diego, USA.
E Barrett-ConnorDepartment of Family Medicine and Public Health, University of California, San Diego, USA.
L K McEvoyDepartment of Radiology, University of California, San Diego, USA.

Funding

Association of Alcohol and Nutrition with Cognition and Brain Structure in AgingR01AA021187 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCEVOY, LINDA KATHLEEN · 2013 to 2017
$2.9M
DHEA REPLACEMENT IN HEALTHY OLDER MEN AND WOMENR01AG018339 · NIA · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI VON MUHLEN, DENISE GOLDANI · 2000 to 2004
$2.5M
CVD Predictors of Cognitive Function Trajectory over 20 YearsR01AG028507 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 2007 to 2010
$1.2M
EPIDEMIOLOGY OF NIDDM AND IGT IN AN ADULT COMMUNITYR01DK031801 · NIDDK · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 1986 to 2000
$606k
NIAAA NIH HHS R01 AA021187NIA NIH HHS R01 AG018339NIA NIH HHS R01 AG028507NIDDK NIH HHS R01 DK031801
6 · The paper itself

Abstract

backgroundEvidence suggests that moderate alcohol consumption may protect against cognitive decline and dementia. However, uncertainty remains over the patterns of drinking that are most beneficial.

objectiveTo examine associations between amount and frequency of alcohol consumption with multiple domains of cognitive function in a well-characterized cohort of older community-dwelling adults in southern California.

designObservational, cross-sectional cohort study.

settingA research visit between 1988-1992 in Rancho Bernardo, California.

participants1624 participants of the Rancho Bernardo Study (mean age ± SD = 73.2 ± 9.3 years).

resultsAmount and frequency of alcohol intake were significantly associated with cognitive function, even after controlling for potentially related health and lifestyle variables. Global and executive function showed positive linear associations with amount and frequency of alcohol intake, whereas visual memory showed an inverted U-shaped association with alcohol intake, with better performance for moderate and infrequent drinkers than for non-drinkers, excessive drinkers or daily drinkers.

conclusionsIn several cognitive domains, moderate, regular alcohol intake was associated with better cognitive function relative to not drinking or drinking less frequently. This suggests that beneficial cognitive effects of alcohol intake may be achieved with low levels of drinking that are unlikely to be associated with adverse effects in an aging population.

Indexed as

Cognitive agingdrinking frequencydrinking quantityexecutive functionvisual memory

Identifiers

PMID27184039
PMCPMC4866612

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.