Evidence map›Paper›PMID 27183902›Full record

ReviewThe lancet. Psychiatry2016

Moving towards causality in attention-deficit hyperactivity disorder: overview of neural and genetic mechanisms.

Eduardo F Gallo, Jonathan Posner

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The lancet. Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04284059 (Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD), which is not on this map. Cited by 110 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 11 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04284059 phase4unknown statusnot on this mapstarted 2021, after this paper: background citation

Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD:A Randomized, Double Blind, Placebo-controlled, Multicentric Trial.

TypeinterventionalSponsorChen LiRan2021 to 2022Enrolled504ConditionsADHDArmsPlacebos, vitamin AD, vitamin D
3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 11 syntheses or guidelines pooled it, 215 citations in OpenAlex.

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  6. Periodontal outcomes of children and adolescents with attention deficit hyperactivity disorder: a systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Eduardo F GalloColumbia University and New York State Psychiatric Institute, New York, NY, USA. Electronic address: GalloEd@nyspi.columbia.edu.
Jonathan PosnerColumbia University and New York State Psychiatric Institute, New York, NY, USA.
Columbia University · USNew York State Psychiatric Institute

Funding

Imaging Stimulant Effects on Emotional Lability in Children with ADHDR01MH101172 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI POSNER, JONATHAN E · 2013 to 2017
$2.6M
D2 receptors in cholinergic interneurons: role in striatal circuitry & motivationK01MH107648 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI GALLO, EDUARDO FRANCISCO · 2015 to 2018
$737k
NIMH NIH HHS K01 MH107648NIMH NIH HHS R01 MH101172
6 · The paper itself

Abstract

Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by developmentally inappropriate levels of inattention and hyperactivity or impulsivity. The heterogeneity of its clinical manifestations and the differential responses to treatment and varied prognoses have long suggested myriad underlying causes. Over the past decade, clinical and basic research efforts have uncovered many behavioural and neurobiological alterations associated with ADHD, from genes to higher order neural networks. Here, we review the neurobiology of ADHD by focusing on neural circuits implicated in the disorder and discuss how abnormalities in circuitry relate to symptom presentation and treatment. We summarise the literature on genetic variants that are potentially related to the development of ADHD, and how these, in turn, might affect circuit function and relevant behaviours. Whether these underlying neurobiological factors are causally related to symptom presentation remains unresolved. Therefore, we assess efforts aimed at disentangling issues of causality, and showcase the shifting research landscape towards endophenotype refinement in clinical and preclinical settings. Furthermore, we review approaches being developed to understand the neurobiological underpinnings of this complex disorder, including the use of animal models, neuromodulation, and pharmacoimaging studies.

Indexed as

Genetic VariationAttention Deficit Disorder with HyperactivityCausalityHumansNerve NetNeurobiology

Identifiers

PMID27183902
PMCPMC4893880
OpenAlexW2352611762

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.