Evidence map›Paper›PMID 27183825›Full record

ArticleRenal failure2016

An electronic alert to decrease Kayexalate ordering.

David E Leaf, Xingxing S Cheng, Jason L Sanders, Mallika Mendu, Gordon D Schiff, David B Mount, Hasan Bazari

Open access · goldAbstract read
In one paragraph

Article in Renal failure, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Serum potassium laboratory reference ranges influence provider treatment behaviors for hyperkalemia.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

David E Leafa Division of Renal Medicine , Brigham and Women's Hospital , Boston , MA , USA.
Xingxing S Chengb Department of Medicine , Massachusetts General Hospital , Boston , MA , USA.
Jason L Sandersd Harvard Affiliated Emergency Medicine Residency, Brigham and Women's Hospital and Massachusetts General Hospital , Boston , MA , USA.
Mallika Mendua Division of Renal Medicine , Brigham and Women's Hospital , Boston , MA , USA.
Gordon D Schiffe Division of General Internal Medicine , Center for Patient Safety Research and Practice, Brigham and Women's Hospital , Boston , MA , USA.
David B Mounta Division of Renal Medicine , Brigham and Women's Hospital , Boston , MA , USA.
Hasan Bazarib Department of Medicine , Massachusetts General Hospital , Boston , MA , USA.
Brigham and Women's Hospital · USMassachusetts General Hospital · US

Funding

TRAINING PROGRAM IN ACADEMIC NEPHROLOGYT32DK007527 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1986 to 2021
$8.8M
Dysregulated Mineral Metabolism and Acute Kidney InjuryK23DK106448 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI LEAF, DAVID EVAN · 2015 to 2019
$964k
NIDDK NIH HHS K23 DK106448NIDDK NIH HHS T32 DK007527
6 · The paper itself

Abstract

Important safety concerns have recently emerged regarding the use of sodium polystyrene sulfonate (Kayexalate), a cation-exchange resin commonly used for the treatment of hyperkalemia. We implemented an electronic alert system at a tertiary care academic medical center to warn providers of the safety concerns of Kayexalate. We assessed the number of Kayexalate prescriptions per month, as well as the number of grams of Kayexalate ordered per month, one year before versus one year after implementing the alert. The mean (±SD) number of Kayexalate orders decreased from 123 (±12) to 76 (±14) orders/month (38% absolute reduction, p < 0.001) after implementing the alert. Additionally, the mean (±SD) amount of Kayexalate prescribed decreased from 3332 (±329) to 1885 (±358) g/month (43% absolute reduction, p < 0.001). We conclude that an electronic alert is an effective tool to decrease Kayexalate ordering.

Indexed as

Medical Order Entry SystemsCation Exchange ResinsDrug MonitoringDrug UtilizationHumansHyperkalemiaMassachusettsPatient SafetyPolystyrenesQuality ImprovementTertiary Care CentersCation Exchange ResinsPolystyrenespolystyrene sulfonic acidElectronic alerthyperkalemiapatient safetypotassiumquality improvement

Identifiers

PMID27183825
PMCPMC5114173
OpenAlexW2397395385

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.