ArticleJournal of immunology (Baltimore, Md. : 1950)2016
Preferential Use of Public TCR during Autoimmune Encephalomyelitis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- T-cell receptor repertoires as potential diagnostic markers for patients with COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Trial
- Article
- Analysis of the TCRβ repertoire characteristics when combining radiotherapy and immunotherapy in cancer.Oncology letters · 2026Article
- Precise identification and tracking of HMGCR-reactive CD4+ T cells in the target tissue of patients with anti-HMGCR immune-mediated necrotising myopathy.Annals of the rheumatic diseases · 2025Article
- Investigation of Long-Term CD4+ T Cell Receptor Repertoire Changes Following SARS-CoV-2 Infection in Patients with Different Severities of Disease.Diagnostics (Basel, Switzerland) · 2024Article
- T cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort.Scientific reports · 2023Article
- Prospects of Cytomegalovirus-Specific T-Cell Receptors in Clinical Diagnosis and Therapy.Viruses · 2023Review
- Article
- Architecture of the SARS-CoV-2-specific T cell repertoire.Frontiers in immunology · 2023Review
- Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage.Genes & genomics · 2022Article
- Activation pathways that drive CD4Immunological reviews · 2022Review
- Analysis of T cell receptor clonotypes in tumor microenvironment identifies shared cancer-type-specific signatures.Cancer immunology, immunotherapy : CII · 2022Article
- GIANA allows computationally-efficient TCR clustering and multi-disease repertoire classification by isometric transformation.Nature communications · 2021Article
- STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets.The Journal of experimental medicine · 2021Article
- Selection influences naive CD8+ TCR-β repertoire sharing.Immunology · 2021Article
- TCRdb: a comprehensive database for T-cell receptor sequences with powerful search function.Nucleic acids research · 2021Article
- VJ Segment Usage of TCR-Beta Repertoire in Monozygotic Cystic Fibrosis Twins.Frontiers in immunology · 2021Article
- High Throughput Human T Cell Receptor Sequencing: A New Window Into Repertoire Establishment and Alloreactivity.Frontiers in immunology · 2021Review
- Partial recovery of disturbed V-J pairing profiles of T-cell receptor in people living with HIV receiving long-term antiretroviral therapy.Science China. Life sciences · 2021Article
- Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
How the TCR repertoire, in concert with risk-associated MHC, imposes susceptibility for autoimmune diseases is incompletely resolved. Due largely to recombinatorial biases, a small fraction of TCRα or β-chains are shared by most individuals, or public. If public TCR chains modulate a TCRαβ heterodimer's likelihood of productively engaging autoantigen, because they are pervasive and often high frequency, they could also broadly influence disease risk and progression. Prior data, using low-resolution techniques, have identified the heavy use of select public TCR in some autoimmune models. In this study, we assess public repertoire representation in mice with experimental autoimmune encephalomyelitis at high resolution. Saturation sequencing was used to identify >18 × 10(6) TCRβ sequences from the CNSs, periphery, and thymi of mice at different stages of autoimmune encephalomyelitis and healthy controls. Analyses indicated the prominent representation of a highly diverse public TCRβ repertoire in the disease response. Preferential formation of public TCR implicated in autoimmunity was identified in preselection thymocytes, and, consistently, public, disease-associated TCRβ were observed to be commonly oligoclonal. Increased TCR sharing and a focusing of the public TCR response was seen with disease progression. Critically, comparisons of peripheral and CNS repertoires and repertoires from preimmune and diseased mice demonstrated that public TCR were preferentially deployed relative to nonshared, or private, sequences. Our findings implicate public TCR in skewing repertoire response during autoimmunity and suggest that subsets of public TCR sequences may serve as disease-specific biomarkers or influence disease susceptibility or progression.
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