ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Characterization of the genetic environment of the blaKPC-2 gene among Klebsiella pneumoniae isolates from a Chinese Hospital.
Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 41 citations in OpenAlex.
- Investigating the prevalence of KPC-2 and the variant KPC-144 in carbapenem-resistant Klebsiella pneumoniae and elucidating its molecular epidemiological and genetic characteristics.BMC microbiology · 2026Article
- Molecular characterization of a clinical ST145mSystems · 2026Article
- Characterization of genetic context ofFrontiers in microbiology · 2025Article
- Review
- Genomic insights and antimicrobial resistance profiles of CRKP and non-CRKP isolates in a Beijing geriatric medical center: emphasizing theFrontiers in microbiology · 2024Article
- Genomic characterization of aFrontiers in cellular and infection microbiology · 2024Article
- Replicative transposition contributes to the evolution and dissemination of KPC-2-producing plasmid inEmerging microbes & infections · 2022Article
- Outbreak of IncX8 Plasmid-Mediated KPC-3-Producing Enterobacterales Infection, China.Emerging infectious diseases · 2022Article
- Distribution of β-Lactamase Genes and Genetic Context ofInfection and drug resistance · 2021Article
- Prevalence of the NTEFrontiers in microbiology · 2021Article
- The Inc FII Plasmid and its Contribution in the Transmission ofAntibiotics (Basel, Switzerland) · 2019Article
- Clonal dissemination of KPC-2-producingAnnals of translational medicine · 2019Article
- Rapid phenotypic evolution in multidrug-resistant Klebsiella pneumoniae hospital outbreak strains.Microbial genomics · 2019Article
- Genomic Analysis Of A KPC-2-ProducingInfection and drug resistance · 2019Article
- Emergence and establishment of KPC-2-producing ST11 Klebsiella pneumoniae in a general hospital in Shanghai, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Further Spread of aFrontiers in microbiology · 2018Article
- Translocation of Carbapenemase GeneAntimicrobial agents and chemotherapy · 2017Article
- Genomic Characterization of Two KPC-Producing Klebsiella Isolates Collected in 1997 in New York City.Antimicrobial agents and chemotherapy · 2017Article
- Article
- Anti-Restriction Protein, KlcAFrontiers in cellular and infection microbiology · 2017Article
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Authors and funding
4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Infection caused by carbapenem-resistant Klebsiella pneumoniae has become a major healthcare threat and KPC-2 enzyme is a dominant factor mediating carbapenems resistance in K. pneumoniae. This study was designed to determine the genetic environment of blaKPC-2, which prevailed in clinical K. pneumoniae isolates recovered in Huashan Hospital, Shanghai, China. Forty-two clinical isolates were included in this study by blaKPC-2 screening. After multilocus sequence typing and plasmid analyses of PCR-based replicon typing (PBRT), junction PCR, mapping PCR and crossing PCR assays, primer walking, and amplicon sequencing were used to analyze the genetic environment of the blaKPC-2 gene. ST423, ST65, ST977, and ST11 were all detected in KPC-2-producing K. pneumoniae. Two types of blaKPC-2-bearing genetic structure were found: Tn1721-blaKPC-2-Tn3 and Tn1721-blaKPC-2-ΔTn3-IS26; and were carried in IncX and IncFII plasmids, respectively. In conclusion, the genetic environment of the blaKPC-2 gene was diverse and Tn1721-blaKPC-2-ΔTn3-IS26 was dominant in clinical K. pneumoniae isolates in Huashan Hospital. This study sheds some light on the genetic environment and should foster further studies about the mechanism of the blaKPC-2 dissemination.
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