Evidence map›Paper›PMID 27183098›Full record

ArticleBone marrow transplantation2016

Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation.

M Mohty, F Malard, M Abecassis, E Aerts, A S Alaskar, M Aljurf, M Arat, P Bader, F Baron, A Bazarbachi and 22 more

4 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone marrow transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 197 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03426358 nacompletednot on this map

Usefulness of Liver Stiffness Measurement in Predicting Hepatic Veno-Occlusive Disease Development in Patients Who Undergo HSCT: a Multicentric Prospective Study

TypeinterventionalSponsorIRCCS Azienda Ospedaliero-Universitaria di BolognaRan2015 to 2021Enrolled1,101ConditionsVeno Occlusive Disease, Hepatic, Sinusoidal Obstruction Syndrome, Stem Cell Transplant ComplicationsArmsLSM assessed by Elastographic Techniques
NCT03858530 naterminatednot on this mapstarted 2018, after this paper: background citation

Using Ultrasound Elastography to Predict Development of Sinusoidal Obstruction Syndrome

TypeinterventionalSponsorChildren's Mercy Hospital Kansas CityRan2018 to 2024Enrolled21ConditionsBone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome, Veno-occlusive Disease, Stem Cell Transplant ComplicationsArmsUltrasound Examination
NCT03865589 nacompletednot on this mapstarted 2019, after this paper: background citation

Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome

TypeinterventionalSponsorChildren's Mercy Hospital Kansas CityRan2019 to 2025Enrolled250ConditionsBone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome, Veno Occlusive Disease, Hepatic, Stem Cell Transplant ComplicationsArmsUltrasound Elastography
NCT04141735 completednot on this map

A Real-life Study About Prediction of Sinusoidal Obstruction Syndrome With Ultrasound and Elastography Before Allogeneic Hematopoietic Stem Cell Transplantation

TypeobservationalSponsorCentral Hospital, Nancy, FranceRan2016 to 2018Enrolled114ConditionsSinusoidal Obstruction SyndromeArmsultrasound
3 · Its place in the literature

Who cites it

197 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

M MohtyHematology Department, Hôpital Saint Antoine, and Université Pierre & Marie Curie, Paris, France.
F MalardHematology Department, Hôpital Saint Antoine, and Université Pierre & Marie Curie, Paris, France.
M AbecassisInstituto Portugues de Oncologia, Lisbon, Portugal.
E AertsDepartment of Haematology, University Hospital Zurich, Zurich, Switzerland.
A S AlaskarKing Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, Department of Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
M AljurfKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
M AratSisli Florence Nightingale Hospital, HSCT Unit, Istanbul, Turkey.
P BaderDivision for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.
F BaronDepartment of Hematology, University of Liege, Liege, Belgium.
A BazarbachiDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon.
D BlaiseBlood and Marrow Transplantation Program, Hematology Department, Institut Paoli-Calmettes, Marseille, France.
F CiceriHematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
S CorbaciogluDepartment of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.
J-H DalleDepartment of Hematology and Immunology, Hospital Robert Debre, Paris 7-Paris Diderot University, Paris, France.
F DignanDepartment of Clinical Haematology, Central Manchester Foundation Trust, Manchester, UK.
T FukudaHSCT division, National Cancer Center Hospital, Tokyo, Japan.
A HuynhHematology Department, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France.
T MassziDepartment of Hematology and Stem Cell Transplantation, St Istvan and St Laszlo Hospital, Budapest 3 Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
M MichalletHematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon EST, Pierre Bénite, France.
A NaglerHematology and Bone Marrow Transplantation, Chaim Sheba Medical center, Tel-Hashomer, Israel.
M NiChonghaileNational Stem Cell Transplant Unit (Adults), Department of Haematology, St James's Hospital and Academic Department of Haematology, Trinity College Dublin, Dublin, Ireland.
S OkamotoDivision of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
A PagliucaDepartment of Haematology, King's College Hospital, London, UK.
C PetersDepartment of Pediatrics, St Anna Kinderspital, Vienna, Austria.ORCID http://orcid.org/0000-0003-0369-8515
F B PetersenLDS Hospital, Salt Lake City, UT, USA.
P G RichardsonDivision of Hematologic Malignancy, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
T RuutuComprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.
B N SavaniHematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, Tennessee.
E WallhultSection of Haematology and Coagulation, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg Sweden.
I Yakoub-AghaCHU de Lille, LIRIC INSERM U995, université de Lille2, France.
R F DuarteDepartment of Hematology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
E CarrerasJosep Carreras Foundation & Leukemia Research Institute, Hematology Department, Hospital Clínic, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.

Indexed as

AdultBiomarkersEarly DiagnosisHematopoietic Stem Cell TransplantationHepatic Veno-Occlusive DiseaseHumansRisk FactorsSensitivity and SpecificitySeverity of Illness IndexBiomarkers

Identifiers

PMID27183098
PMCPMC4935979

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.