ArticleeLife2016
Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Spatial transcriptomics profiling across tissue boundaries in the developing mouse brain.iScience · 2026Article
- Planar cell polarity-directed cell crawling drives polarized epithelial morphogenesis.Current biology : CB · 2026Article
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- Toll receptors mediate tissue intrinsic surveillance against aberrant cells by detecting cell fate aberrations.Development (Cambridge, England) · 2026Article
- Modeling of viscous frictional force in multicellular morphogenesis.Biophysics and physicobiology · 2026Article
- A Framework for Automated Tracking of Morphologically Distinct Cell Populations in Time-Lapse Microscopy....IEEE...International Conference on Connected Health: Applications, Systems and Engineering Technologies. IEEE International Conference on Connected Health: Applications, Systems and Engineering Technologies · 2026Article
- Supracellular actomyosin assemblies: master coordinators of development.Development (Cambridge, England) · 2025Review
- Vertex models capturing subcellular scales in epithelial tissues.PLoS computational biology · 2025Review
- Rectification of planar orientation angle switches behavior and replenishes contractile junctions.The Journal of cell biology · 2025Article
- Single-cell analysis of the early Drosophila salivary gland reveals that morphogenetic control involves both the induction and exclusion of gene expression programs.PLoS biology · 2025Article
- Unsupervised spatiotemporal classification of deformation patterns of embryonic tissues matches their fate map.iScience · 2025Article
- Vertex model with internal dissipation enables sustained flows.Nature communications · 2025Article
- E-cadherin tunes tissue mechanical behavior before and during morphogenetic tissue flows.Current biology : CB · 2024Article
- Mechanical stress combines with planar polarised patterning during metaphase to orient embryonic epithelial cell divisions.Development (Cambridge, England) · 2024Article
- Polarised cell intercalation during Drosophila axis extension is robust to an orthogonal pull by the invaginating mesoderm.PLoS biology · 2024Article
- Serotonin signaling regulates actomyosin contractility during morphogenesis in evolutionarily divergent lineages.Nature communications · 2023Article
- Striped Expression of Leucine-Rich Repeat Proteins Coordinates Cell Intercalation and Compartment Boundary Formation in the EarlySymmetry · 2023Article
- Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins.Molecular biology of the cell · 2023Article
- Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins.bioRxiv : the preprint server for biology · 2023Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Convergence and extension movements elongate tissues during development. Drosophila germ-band extension (GBE) is one example, which requires active cell rearrangements driven by Myosin II planar polarisation. Here, we develop novel computational methods to analyse the spatiotemporal dynamics of Myosin II during GBE, at the scale of the tissue. We show that initial Myosin II bipolar cell polarization gives way to unipolar enrichment at parasegmental boundaries and two further boundaries within each parasegment, concomitant with a doubling of cell number as the tissue elongates. These boundaries are the primary sites of cell intercalation, behaving as mechanical barriers and providing a mechanism for how cells remain ordered during GBE. Enrichment at parasegment boundaries during GBE is independent of Wingless signaling, suggesting pair-rule gene control. Our results are consistent with recent work showing that a combinatorial code of Toll-like receptors downstream of pair-rule genes contributes to Myosin II polarization via local cell-cell interactions. We propose an updated cell-cell interaction model for Myosin II polarization that we tested in a vertex-based simulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.