Evidence map›Paper›PMID 27182900›Full record

ReviewMass spectrometry reviews2018

Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism.

Daniel James Wilkinson

Open access · hybridAbstract readHistorical ArticleReview
In one paragraph

Review in Mass spectrometry reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. A Stable Isotope Tracing Primer for the Mass Spectrometrist.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Urinary metabolome dynamics inMetabolomics : Official journal of the Metabolomic Society · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Surface-Dependent Isotopic Adsorption of CO on α-AlMolecules (Basel, Switzerland) · 2025
    Article
  13. Review
  14. Article
  15. Muscle Proteome Dynamics.Advances in experimental medicine and biology · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Metabolomic and proteomic applications to exercise biomedicine.Translational exercise biomedicine · 2024
    Review
  20. Understanding HDL Metabolism and Biology Through In Vivo Tracer Kinetics.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Daniel James WilkinsonMRC-ARUK Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, United Kingdom.
University of Nottingham · GB

Funding

Arthritis Research UK 19891Medical Research Council MR/K00414X/1Medical Research Council MR/P021220/1Versus Arthritis 19891
6 · The paper itself

Abstract

Over a century ago, Frederick Soddy provided the first evidence for the existence of isotopes; elements that occupy the same position in the periodic table are essentially chemically identical but differ in mass due to a different number of neutrons within the atomic nucleus. Allied to the discovery of isotopes was the development of some of the first forms of mass spectrometers, driven forward by the Nobel laureates JJ Thomson and FW Aston, enabling the accurate separation, identification, and quantification of the relative abundance of these isotopes. As a result, within a few years, the number of known isotopes both stable and radioactive had greatly increased and there are now over 300 stable or radioisotopes presently known. Unknown at the time, however, was the potential utility of these isotopes within biological disciplines, it was soon discovered that these stable isotopes, particularly those of carbon (

Indexed as

AnimalsCarbon IsotopesDeuteriumEquipment DesignHistory, 20th CenturyHistory, 21st CenturyHumansIsotope LabelingMass SpectrometryNitrogen IsotopesOxygen IsotopesProteinsCarbon IsotopesDeuteriumNitrogen-15Nitrogen IsotopesOxygen-18Oxygen IsotopesProteinsmass spectrometryprotein metabolismstable isotopes

Identifiers

PMID27182900
PMCPMC5763415
OpenAlexW2406065185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.