ArticlePloS one2016
Impact of Wild Loci on the Allergenic Potential of Cultivated Tomato Fruits.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 8 citations in OpenAlex.
- Safety evaluation of the food enzyme endo-polygalacturonase from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme containing endo-polygalacturonase, pectinesterase, pectin lyase and arabinan endo-1,5-α-l-arabinanase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme containing endo-polygalacturonase and pectinesterase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme endo-polygalacturonase from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of a food enzyme containing arabinan endo-1,5-α-l-arabinanase and endo-polygalacturonase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of a food enzyme containing endo-polygalacturonase and pectin lyase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme containing endo-polygalacturonase and pectinesterase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of a food enzyme containing endo-polygalacturonase, pectinesterase and pectin lyase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Suppressed Expression of Allergenic Transcripts in Different Tomato Cultivars Are Linked with Increased Antioxidant Capacity.International journal of molecular sciences · 2025Article
- Safety evaluation of the food enzyme endo-polygalacturonase from the genetically modifiedEFSA journal. European Food Safety Authority · 2025Article
- Identification of non-specific Lipid Transfer Protein gene family members in Solanum lycopersicum and insights into the features of Sola l 3 protein.Scientific reports · 2019Article
- High-resolution spatiotemporal transcriptome mapping of tomato fruit development and ripening.Nature communications · 2018Article
- Effect of tomato variety, cultivation, climate and processing on Sola l 4, an allergen from Solanum lycopersicum.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tomato (Solanum lycopersicum) is one of the most extensively consumed vegetables but, unfortunately, it is also able to induce allergic reactions. In the past, it has been shown that the choice of tomato cultivar significantly influenced the allergic reaction of tomato allergic subjects. In this study we investigated the allergenic potential of the cultivated tomato line M82 and of two selected lines carrying small chromosome regions from the wild species Solanum pennellii (i.e. IL7-3 and IL12-4). We evaluated the positive interactions of IgEs of allergic subjects in order to investigate the different allergenic potential of the lines under investigation. We used proteomic analyses in order to identify putative tomato allergens. In addition, bioinformatic and transcriptomic approaches were applied in order to analyse the structure and the expression profiles of the identified allergen-encoding genes. These analyses demonstrated that fruits harvested from the two selected introgression lines harbour a different allergenic potential as those from the cultivated genotype M82. The different allergenicity found within the three lines was mostly due to differences in the IgE recognition of a polygalacturonase enzyme (46 kDa), one of the major tomato allergens, and of a pectin methylesterase (34 kDa); both the proteins were more immunoreactive in IL7-3 compared to IL12-4 and M82. The observed differences in the allergenic potential were mostly due to line-dependent translational control or post-translational modifications of the allergens. We demonstrated, for the first time, that the introgression from a wild species (S. pennellii) in the genomic background of a cultivated tomato line influences the allergenic properties of the fruits. Our findings could support the isolation of favorable wild loci promoting low allergenic potential in tomato.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.