Evidence map›Paper›PMID 27182621›Full record

ArticleMolecular endocrinology (Baltimore, Md.)2016

The Genomic Context and Corecruitment of SP1 Affect ERRα Coactivation by PGC-1α in Muscle Cells.

Silvia Salatino, Barbara Kupr, Mario Baresic, Saeed Omidi, Erik van Nimwegen, Christoph Handschin

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular endocrinology (Baltimore, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Impaired age-associated mitochondrial translation is mitigated by exercise and PGC-1α.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Article
  4. Review
  5. Innately expressed estrogen-related receptors in the skeletal muscle are indispensable for exercise fitness.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations.Cold Spring Harbor perspectives in medicine · 2017
    Review
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Silvia SalatinoFocal Area Growth and Development (S.S., B.K., M.B., C.H.) and Focal Area Computational and Systems Biology (S.S., E.N.), Biozentrum, University of Basel, and Swiss Institute of Bioinformatics (S.S., E.N.), CH-4056 Basel, Switzerland.
Barbara KuprFocal Area Growth and Development (S.S., B.K., M.B., C.H.) and Focal Area Computational and Systems Biology (S.S., E.N.), Biozentrum, University of Basel, and Swiss Institute of Bioinformatics (S.S., E.N.), CH-4056 Basel, Switzerland.
Mario BaresicFocal Area Growth and Development (S.S., B.K., M.B., C.H.) and Focal Area Computational and Systems Biology (S.S., E.N.), Biozentrum, University of Basel, and Swiss Institute of Bioinformatics (S.S., E.N.), CH-4056 Basel, Switzerland.
Saeed Omidi
Erik van NimwegenFocal Area Growth and Development (S.S., B.K., M.B., C.H.) and Focal Area Computational and Systems Biology (S.S., E.N.), Biozentrum, University of Basel, and Swiss Institute of Bioinformatics (S.S., E.N.), CH-4056 Basel, Switzerland.
Christoph HandschinFocal Area Growth and Development (S.S., B.K., M.B., C.H.) and Focal Area Computational and Systems Biology (S.S., E.N.), Biozentrum, University of Basel, and Swiss Institute of Bioinformatics (S.S., E.N.), CH-4056 Basel, Switzerland.
SIB Swiss Institute of Bioinformatics · CHUniversity of Basel · CH

Funding

European Research Council 616830Wellcome Trust
6 · The paper itself

Abstract

The peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) coordinates the transcriptional network response to promote an improved endurance capacity in skeletal muscle, eg, by coactivating the estrogen-related receptor-α (ERRα) in the regulation of oxidative substrate metabolism. Despite a close functional relationship, the interaction between these 2 proteins has not been studied on a genomic level. We now mapped the genome-wide binding of ERRα to DNA in a skeletal muscle cell line with elevated PGC-1α and linked the DNA recruitment to global PGC-1α target gene regulation. We found that, surprisingly, ERRα coactivation by PGC-1α is only observed in the minority of all PGC-1α recruitment sites. Nevertheless, a majority of PGC-1α target gene expression is dependent on ERRα. Intriguingly, the interaction between these 2 proteins is controlled by the genomic context of response elements, in particular the relative GC and CpG content, monomeric and dimeric repeat-binding site configuration for ERRα, and adjacent recruitment of the transcription factor specificity protein 1. These findings thus not only reveal a novel insight into the regulatory network underlying muscle cell plasticity but also strongly link the genomic context of DNA-response elements to control transcription factor-coregulator interactions.

Indexed as

AnimalsBase CompositionCell LineChromatin ImmunoprecipitationCpG IslandsERRalpha Estrogen-Related ReceptorMiceMuscle Fibers, SkeletalPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPrincipal Component AnalysisReceptors, EstrogenRNA, Small InterferingSp1 Transcription FactorERRalpha Estrogen-Related ReceptorPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseReceptors, EstrogenRNA, Small InterferingSp1 Transcription Factor

Identifiers

PMID27182621
PMCPMC4970653
OpenAlexW2399277610

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.