ArticlePloS one2016
Serum Folate Shows an Inverse Association with Blood Pressure in a Cohort of Chinese Women of Childbearing Age: A Cross-Sectional Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.Journal of human hypertension · 2024Article
- Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes.Epigenomics · 2023Article
- Association between plasma levels of homocysteine, folate, and vitamin BScientific reports · 2020Article
- The Folate Concentration and/or Folic Acid Metabolites in Plasma as Factor for COVID-19 Infection.Frontiers in pharmacology · 2020Article
- Association between homocysteine level and blood pressure traits among Tibetans: A cross-sectional study in China.Medicine · 2019Article
- Trajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
9 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundIt has been reported that higher folate intake from food and supplementation is associated with decreased blood pressure (BP). The association between serum folate concentration and BP has been examined in few studies. We aim to examine the association between serum folate and BP levels in a cohort of young Chinese women.
methodsWe used the baseline data from a pre-conception cohort of women of childbearing age in Liuyang, China, for this study. Demographic data were collected by structured interview. Serum folate concentration was measured by immunoassay, and homocysteine, blood glucose, triglyceride and total cholesterol were measured through standardized clinical procedures. Multiple linear regression and principal component regression model were applied in the analysis.
resultsA total of 1,532 healthy normotensive non-pregnant women were included in the final analysis. The mean concentration of serum folate was 7.5 ± 5.4 nmol/L and 55% of the women presented with folate deficiency (< 6.8 nmol/L). Multiple linear regression and principal component regression showed that serum folate levels were inversely associated with systolic and diastolic BP, after adjusting for demographic, anthropometric, and biochemical factors.
conclusionsSerum folate is inversely associated with BP in non-pregnant women of childbearing age with high prevalence of folate deficiency.
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