Evidence map›Paper›PMID 27182559›Full record

ArticlePapillomavirus research (Amsterdam, Netherlands)2016

T cell ignorance is bliss: T cells are not tolerized by Langerhans cells presenting human papillomavirus antigens in the absence of costimulation.

Andrew W Woodham, Lisa Yan, Joseph G Skeate, Daniel van der Veen, Heike H Brand, Michael K Wong, Diane M Da Silva, W Martin Kast

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Papillomavirus research (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Modulation of antigen presenting cell functions during chronic HPV infection.Papillomavirus research (Amsterdam, Netherlands) · 2017
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Andrew W WoodhamDepartment of Molecular Microbiology & Immunology, University of Southern California, Los Angeles, California, United States of America.
Lisa YanDepartment of Molecular Microbiology & Immunology, University of Southern California, Los Angeles, California, United States of America.
Joseph G SkeateDepartment of Molecular Microbiology & Immunology, University of Southern California, Los Angeles, California, United States of America.
Daniel van der VeenLeiden University Medical Center, Leiden, The Netherlands.
Heike H BrandNorris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America.
Michael K WongNorris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America.
Diane M Da SilvaNorris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America; Department of Obstetrics & Gynecology, University of Southern California, Los Angeles, California, United States of America.
W Martin KastDepartment of Molecular Microbiology & Immunology, University of Southern California, Los Angeles, California, United States of America; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America; Department of Obstetrics & Gynecology, University of Southern California, Los Angeles, California, United States of America.
University of Southern California · USLeiden University Medical Center · NL

Funding

VLP VACCINES AGAINST HPV INDUCED TUMORSR01CA074397 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAST, WIJBE MARTIN · 1997 to 2020
$5.5M
Southern California Clinical and Translational Science InstituteTL1TR000132 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2014
$491k
NCATS NIH HHS TL1 TR000132NCI NIH HHS R01 CA074397
6 · The paper itself

Abstract

Human papillomavirus type 16 (HPV16) infections are intra-epithelial, and thus, HPV16 is known to interact with Langerhans cells (LCs), the resident epithelial antigen-presenting cells (APCs). The current paradigm for APC-mediated induction of T cell anergy is through delivery of T cell receptor signals via peptides on MHC molecules (signal 1), but without costimulation (signal 2). We previously demonstrated that LCs exposed to HPV16

Indexed as

Antigen PresentationImmune ToleranceAntigen-Presenting CellsAntigens, ViralCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCellular SenescenceChemokinesCostimulatory and Inhibitory T-Cell ReceptorsCytokinesHuman papillomavirus 16HumansInterleukin-2Langerhans CellsLymphocyte ActivationT-Lymphocytes, RegulatoryAntigens, ViralChemokinesCostimulatory and Inhibitory T-Cell ReceptorsCytokinesInterleukin-2HPV16Human papillomavirusImmune toleranceLangerhans cellsT cell anergyT cell ignorance

Identifiers

PMID27182559
PMCPMC4862606
OpenAlexW2252527272

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.