Evidence map›Paper›PMID 27182155›Full record

ReviewWorld journal of gastroenterology2016

Liver transplantation: Current status and challenges.

Caroline C Jadlowiec, Timucin Taner

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05944042 (Hepatic Transplantation Registry), which is not on this map. Cited by 133 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 3 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05944042 unknown statusnot on this mapstarted 2023, after this paper: background citation

Hepatic Transplantation Registry

Typeobservational_patient_registrySponsorMethodist Health SystemRan2023 to 2025Enrolled300ConditionsIdentify More Accurate Predictive Models of Transplant Risk to Monitor and Evaluate New and Existing Patient FactorsArmsObservational Transplant Analysis
3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 3 syntheses or guidelines pooled it, 299 citations in OpenAlex.

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73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Caroline C JadlowiecCaroline C Jadlowiec, Timucin Taner, William J. von Liebig Transplantation Center, Division of Transplant Surgery, Department of Surgery, Mayo Clinic, Rochester, MN 55905, United States.
Timucin TanerCaroline C Jadlowiec, Timucin Taner, William J. von Liebig Transplantation Center, Division of Transplant Surgery, Department of Surgery, Mayo Clinic, Rochester, MN 55905, United States.
Mayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Great progress has been made in the field of liver transplantation over the past two decades. This progress, however, also brings up the next set of challenges: First, organ shortage remains a major limitation, and accounts for a large proportion of wait list mortality. While living donation has successfully increased the total number of liver transplants done in Asian countries, the total number of such transplants has been stagnant in the western hemisphere. As such, there has been a significant effort over the past decade to increase the existing deceased donor pool. This effort has resulted in a greater use of liver allografts following donation after cardiac death (DCD) along with marginal and extended criteria donors. Improved understanding of the pathophysiology of liver allografts procured after circulatory arrest has not only resulted in better selection and management of DCD donors, but has also helped in the development of mechanical perfusion strategies. Early outcomes demonstrating the clinical applicability of both hypothermic and normothermic perfusion and its potential to impact patient survival and allograft function have generated much interest. Second, long-term outcomes of liver transplant recipients have not improved significantly, as recipients continue to succumb to complications of long-term immunosuppression, such as infection, malignancy and renal failure. Furthermore, recent evidence suggests that chronic immune-mediated injury to the liver may also impact graft function.

Indexed as

AllograftsAnimalsDonor SelectionGraft RejectionGraft SurvivalHumansImmunosuppressive AgentsLiver TransplantationPerfusionRisk FactorsTime FactorsTissue DonorsTreatment OutcomeImmunosuppressive AgentsAntibody-mediated rejectionDonation after cardiac deathMechanical perfusionRenal-sparing immunosuppression

Identifiers

PMID27182155
PMCPMC4858627
OpenAlexW2375924265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.