ArticleIEEE transactions on nuclear science2016
Design of a Multi-Pinhole Collimator for I-123 DaTscan Imaging on Dual-Headed SPECT Systems in Combination with a Fan-Beam Collimator.
Article in IEEE transactions on nuclear science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Delayed convergence of iterative reconstruction in dopamine transporter SPECT with multiple-pinhole collimators.Zeitschrift fur medizinische Physik · 2026Article
- Feasibility study of multi Laue lens based SPECT with a dedicated 3D reconstruction algorithm using Monte Carlo simulations.Scientific reports · 2025Article
- Characterization of accurate 3D collimator-detector response function for single- and multi-lofthole collimated SPECT cameras.Japanese journal of radiology · 2024Article
- Multi-pinhole collimator design in different numbers of projections for brain SPECT.Frontiers in medicine · 2023Article
- Multiple-pinhole collimators improve intra- and between-rater agreement and the certainty of the visual interpretation in dopamine transporter SPECT.EJNMMI research · 2022Article
- Improved Performance of a Multipinhole SPECT for DAT Imaging by Increasing Number of Pinholes at the Expense of Increased Multiplexing.IEEE transactions on radiation and plasma medical sciences · 2021Article
- Cerebral SPECT imaging with different acquisition schemes using varying levels of multiplexing versus sensitivity in an adaptive multi-pinhole brain-dedicated scanner.Biomedical physics & engineering express · 2021Article
- Self-Collimating SPECT With Multi-Layer Interspaced Mosaic Detectors.IEEE transactions on medical imaging · 2021Article
- Improvement in sampling and modulation of multiplexing with temporal shuttering of adaptable apertures in a brain-dedicated multi-pinhole SPECT system.Physics in medicine and biology · 2021Article
- Inclusion of quasi-vertex views in a brain-dedicated multi-pinhole SPECT system for improved imaging performance.Physics in medicine and biology · 2021Article
- Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging.IEEE transactions on medical imaging · 2020Article
- The clinical utilities of multi-pinhole single photon emission computed tomography.Quantitative imaging in medicine and surgery · 2020Review
- Primary, scatter, and penetration characterizations of parallel-hole and pinhole collimators for I-123 SPECT.Physics in medicine and biology · 2019Article
- Simulations of a Multi-Pinhole SPECT Collimator for Clinical Dopamine Transporter (DAT) Imaging.IEEE transactions on radiation and plasma medical sciences · 2018Article
- Evaluation of the Reconstruction Parameters of Brain Dopamine Transporter SPECT images Obtained by a Fan Beam Collimator: A Comparison with Parallel-hole Collimators.Asia Oceania journal of nuclear medicine & biology · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
For the 2011 FDA approved Parkinson's Disease (PD) SPECT imaging agent I-123 labeled DaTscan, the volume of interest (VOI) is the interior portion of the brain. However imaging of the occipital lobe is also required with PD for calculation of the striatal binding ratio (SBR), a parameter of significance in early diagnosis, differentiation of PD from other disorders with similar clinical presentations, and monitoring progression. Thus we propose the usage of a combination of a multi-pinhole (MPH) collimator on one head of the SPECT system and a fan-beam on the other. The MPH would be designed to provide high resolution and sensitivity for imaging of the interior portion of the brain. The fan-beam collimator would provide lower resolution but complete sampling of the brain addressing data sufficiency and allowing a volume-of-interest to be defined over the occipital lobe for calculation of SBR's. Herein we focus on the design of the MPH component of the combined system. Combined reconstruction will be addressed in a subsequent publication. An analysis of 46 clinical DaTscan studies was performed to provide information to define the VOI, and design of a MPH collimator to image this VOI. The system spatial resolution for the MPH was set to 4.7 mm, which is comparable to that of clinical PET systems, and significantly smaller than that of fan-beam collimators employed in SPECT. With this set, we compared system sensitivities for three aperture array designs, and selected the 3 × 3 array due to it being the highest of the three. The combined sensitivity of the apertures for it was similar to that of an ultra-high resolution fan-beam (LEUHRF) collimator, but smaller than that of a high-resolution fan-beam collimator (LEHRF). On the basis of these results we propose the further exploration of this design through simulations, and the development of combined MPH and fan-beam reconstruction.
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