Evidence map›Paper›PMID 27182046›Full record

ArticlePhysiology & behavior2016

Estrogen and insulin transport through the blood-brain barrier.

Aaron A May, Nicholas D Bedel, Ling Shen, Stephen C Woods, Min Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aaron A MayDepartment of Pathology and Molecular Medicine, Metabolic Diseases Institute, University of Cincinnati College of Medicine, OH, USA.
Nicholas D BedelDepartment of Pathology and Molecular Medicine, Metabolic Diseases Institute, University of Cincinnati College of Medicine, OH, USA.
Ling ShenDepartment of Pathology and Molecular Medicine, Metabolic Diseases Institute, University of Cincinnati College of Medicine, OH, USA.
Stephen C WoodsDepartment of Psychiatry and Behavioral Neuroscience, Metabolic Diseases Institute, University of Cincinnati College of Medicine, OH, USA.
Min LiuDepartment of Pathology and Molecular Medicine, Metabolic Diseases Institute, University of Cincinnati College of Medicine, OH, USA. Electronic address: min.liu@uc.edu.

Funding

INSULIN AND CNS CONTROL OF BODY WEIGHT AND FOOD INTAKER01DK017844 · NIDDK · UNIVERSITY OF WASHINGTON · PI WOODS, STEPHEN C · 1986 to 2013
$3.8M
Training Program in Neuroendocrinology of HomeostasisT32DK059803 · NIDDK · UNIVERSITY OF CINCINNATI · PI WOODS, STEPHEN C · 2001 to 2017
$2.8M
Brain apoA-IV Mediates Estrogenic Reduction of Dietary Obesity in Female RatsR01DK092779 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN, WOODS, STEPHEN C · 2011 to 2015
$1.8M
Ginsenocide Rb1: A Novel Anti-Obesity and Anti-Hyperglycemic CompoundR01DK095440 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN, WOODS, STEPHEN C · 2012 to 2016
$1.6M
Regulation of Food Intake and Body Weight by Brain Apo ER01DK070992 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN · 2007 to 2011
$1.4M
INSULIN AND CNS CONTROL OF BODY WEIGHT AND FOOD INTAKER37DK017844 · NIDDK · UNIVERSITY OF WASHINGTON · PI WOODS, STEPHEN C · 1993 to 2000
$382k
NIDDK NIH HHS R01 DK017844NIDDK NIH HHS R01 DK070992NIDDK NIH HHS R01 DK092779NIDDK NIH HHS R01 DK095440NIDDK NIH HHS R37 DK017844NIDDK NIH HHS T32 DK059803
6 · The paper itself

Abstract

Obesity is associated with insulin resistance and reduced transport of insulin through the blood-brain barrier (BBB). Reversal of high-fat diet-induced obesity (HFD-DIO) by dietary intervention improves the transport of insulin through the BBB and the sensitivity of insulin in the brain. Although both insulin and estrogen (E2), when given alone, reduce food intake and body weight via the brain, E2 actually renders the brain relatively insensitive to insulin's catabolic action. The objective of these studies was to determine if E2 influences the ability of insulin to be transported into the brain, since the receptors for both E2 and insulin are found in BBB endothelial cells. E2 (acute or chronic) was systemically administered to ovariectomized (OVX) female rats and male rats fed a chow or a high-fat diet. Food intake, body weight and other metabolic parameters were assessed along with insulin entry into the cerebrospinal fluid (CSF). Acute E2 treatment in OVX female and male rats reduced body weight and food intake, and chronic E2 treatment prevented or partially reversed high-fat diet-induced obesity. However, none of these conditions increased insulin transport into the CNS; rather, chronic E2 treatment was associated less-effective insulin transport into the CNS relative to weight-matched controls. Thus, the reduction of brain insulin sensitivity by E2 is unlikely to be mediated by increasing the amount of insulin entering the CNS.

Indexed as

AnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Blood-Brain BarrierBlood VesselsBody WeightBrainDietary FatsEstrogensFemaleGlucose Transporter Type 1InsulinInsulin ResistanceMaleObesityOvariectomyRatsATP Binding Cassette Transporter, Subfamily B, Member 1Dietary FatsEstrogensGlucose Transporter Type 1InsulinSynaptophysin17β-EstradiolBlood-brain barrierCNS insulin transportDiet-induced obesityInsulin resistanceMetabolic syndrome

Identifiers

PMID27182046
PMCPMC4947438

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.