ArticleScientific reports2016
Self-regenerating and hybrid irreversible/reversible PDMS microfluidic devices.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Overcoming technological barriers in microfluidics: Leakage testing.Frontiers in bioengineering and biotechnology · 2022Pooled it
- Reversible Microfluidic Platform for Spheroid Culturing, Downstream Characterization, and Dynamic Anticancer Susceptibility Testing.ACS measurement science au · 2026Article
- From single cell analysis to 3D micro physiological systems: microfluidic tools integrating cancer cell targets for delineating natural killer cell biology.Microsystems & nanoengineering · 2026Review
- Reversibly-sealable microfluidic platform for multi-molecule gradient delivery to large adherent cell cultures.Biomedical microdevices · 2026Article
- Correction to "Touch-Enabled Reversible Microfluidic Ultradense Chips for Convenient, High-Throughput Electrochemical Assays".ACS applied materials & interfaces · 2025Article
- A review of organ-on-chip fabrication methods: From early developments to overcoming inert barriers.iScience · 2025Review
- Touch-Enabled Reversible Microfluidic Ultradense Chips for Convenient, High-Throughput Electrochemical Assays.ACS applied materials & interfaces · 2025Article
- Article
- Development of a sticker sealed microfluidic device for in situ analytical measurements using synchrotron radiation.Scientific reports · 2021Article
- Risk assessment on-a-chip: a cell-based microfluidic device for immunotoxicity screening.Nanoscale advances · 2021Article
- High-Identical Numerical Aperture, Multifocal Microlens Array through Single-Step Multi-Sized Hole Patterning Photolithography.Micromachines · 2020Article
- Rapid Fabrication of Membrane-Integrated Thermoplastic Elastomer Microfluidic Devices.Micromachines · 2020Article
- Transparent PDMS Bioreactors for the Fabrication and Analysis of Multi-Layer Pre-vascularized Hydrogels Under Continuous Perfusion.Frontiers in bioengineering and biotechnology · 2020Article
- Stretchable materials of high toughness and low hysteresis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- PVA-PDMS-Stearic acid composite nanofibrous mats with improved mechanical behavior for selective filtering applications.Scientific reports · 2018Article
- Detection of Chloroalkanes by Surface-Enhanced Raman Spectroscopy in Microfluidic Chips.Sensors (Basel, Switzerland) · 2018Article
- Large-Area and High-Throughput PDMS Microfluidic Chip Fabrication Assisted by Vacuum Airbag Laminator.Micromachines · 2017Article
- Plasma free reversible and irreversible microfluidic bonding.Lab on a chip · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper outlines a straightforward, fast, and low-cost method to fabricate polydimethylsiloxane (PDMS) chips. Termed sandwich bonding (SWB), this method requires only a laboratory oven. Initially, SWB relies on the reversible bonding of a coverslip over PDMS channels. The coverslip is smaller than the substrate, leaving a border around the substrate exposed. Subsequently, a liquid composed of PDMS monomers and a curing agent is poured onto the structure. Finally, the cover is cured. We focused on PDMS/glass chips because of their key advantages in microfluidics. Despite its simplicity, this method created high-performance microfluidic channels. Such structures featured self-regeneration after leakages and hybrid irreversible/reversible behavior. The reversible nature was achieved by removing the cover of PDMS with acetone. Thus, the PDMS substrate and glass coverslip could be detached for reuse. These abilities are essential in the stages of research and development. Additionally, SWB avoids the use of surface oxidation, half-cured PDMS as an adhesive, and surface chemical modification. As a consequence, SWB allows surface modifications before the bonding, a long time for alignment, the enclosure of sub-micron channels, and the prototyping of hybrid devices. Here, the technique was successfully applied to bond PDMS to Au and Al.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.