ArticleScientific reports2016
Usp9x-deficiency disrupts the morphological development of the postnatal hippocampal dentate gyrus.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Metabolomic Differentiation of Malpighiaceae From Dry and Humid Tropics via UHPLC-MS/MS and Chemometrics.Analytical science advances · 2026Article
- Deubiquitinating enzymes at the crossroads of blood-brain barrier integrity and neurodegeneration: mechanistic insights, therapeutic targeting and future directions.Tissue barriers · 2026Review
- Sox5 controls cell cycle progression in intermediate progenitor cells during dentate gyrus development.Frontiers in cell and developmental biology · 2026Article
- The Hippo effector TEAD1 regulates postnatal murine cerebellar development.Brain structure & function · 2025Article
- Male mice are susceptible to brain dysfunction induced by early-life acephate exposure.Frontiers in neuroscience · 2024Article
- Comparison of Serum USP9x and TGF-β Levels in Children with Autism Spectrum Disorders with Healthy Controls.Noro psikiyatri arsivi · 2024Article
- Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- TBK1 Knockdown Alleviates Axonal Transport Deficits in Retinal Ganglion Cells Via mTORC1 Activation in a Retinal Damage Mouse Model.Investigative ophthalmology & visual science · 2023Article
- Roles and mechanisms of ankyrin-G in neuropsychiatric disorders.Experimental & molecular medicine · 2022Review
- Protein clearance strategies for disease intervention.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development.Nature communications · 2021Article
- Deubiquitylating enzymes in neuronal health and disease.Cell death & disease · 2021Review
- Missense variant contribution to USP9X-female syndrome.NPJ genomic medicine · 2020Article
- Effects of early life exposure to traffic-related air pollution on brain development in juvenile Sprague-Dawley rats.Translational psychiatry · 2020Article
- Early Ethanol Exposure Inhibits the Differentiation of Hippocampal Dentate Gyrus Granule Cells in a Mouse Model of Fetal Alcohol Spectrum Disorders.Alcoholism, clinical and experimental research · 2020Article
- Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development.Neuron · 2020Article
- Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling.Biological psychiatry · 2020Article
- Whole-exome sequencing reveals novelClinical case reports · 2019Article
- Heterozygosity for Nuclear Factor One X in mice models features of Malan syndrome.EBioMedicine · 2019Article
- Cellular functions of stem cell factors mediated by the ubiquitin-proteasome system.Cellular and molecular life sciences : CMLS · 2018Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within the adult mammalian brain, neurogenesis persists within two main discrete locations, the subventricular zone lining the lateral ventricles, and the hippocampal dentate gyrus. Neurogenesis within the adult dentate gyrus contributes to learning and memory, and deficiencies in neurogenesis have been linked to cognitive decline. Neural stem cells within the adult dentate gyrus reside within the subgranular zone (SGZ), and proteins intrinsic to stem cells, and factors within the niche microenvironment, are critical determinants for development and maintenance of this structure. Our understanding of the repertoire of these factors, however, remains limited. The deubiquitylating enzyme USP9X has recently emerged as a mediator of neural stem cell identity. Furthermore, mice lacking Usp9x exhibit a striking reduction in the overall size of the adult dentate gyrus. Here we reveal that the development of the postnatal SGZ is abnormal in mice lacking Usp9x. Usp9x conditional knockout mice exhibit a smaller hippocampus and shortened dentate gyrus blades from as early as P7. Moreover, the analysis of cellular populations within the dentate gyrus revealed reduced stem cell, neuroblast and neuronal numbers and abnormal neuroblast morphology. Collectively, these findings highlight the critical role played by USP9X in the normal morphological development of the postnatal dentate gyrus.
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