ArticlePharmaceutical biology2016
Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice.
Article in Pharmaceutical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Correlation between depressive-like behavior and gut microbiota in mice with hypothyroidism.World journal of psychiatry · 2025Article
- Isolation and Bioassay of Linear Veraguamides from a Marine Cyanobacterium (Molecules (Basel, Switzerland) · 2025Article
- Isolation and Bioassay of Linear Veraguamides from a Marine Cyanobacterium (bioRxiv : the preprint server for biology · 2025Article
- rTMS ameliorates depressive-like behaviors and regulates the gut microbiome and medium- and long-chain fatty acids in mice exposed to chronic unpredictable mild stress.CNS neuroscience & therapeutics · 2023Article
- Barbamide Displays Affinity for Membrane-Bound Receptors and Impacts Store-Operated Calcium Entry in Mouse Sensory Neurons.Marine drugs · 2023Article
- Fructus gardeniae ameliorates anxiety-like behaviors induced by sleep deprivation via regulating hippocampal metabolomics and gut microbiota.Frontiers in cellular and infection microbiology · 2023Article
- Slow-sustained delivery of naloxone reduces typical naloxone-induced precipitated opioid withdrawal effects in male morphine-dependent mice.Journal of neuroscience research · 2022Article
- Profile of gut microbiota in patients with traumatic thoracic spinal cord injury and its clinical implications: a case-control study in a rehabilitation setting.Bioengineered · 2021Article
- Cyanobacterial extract with serotonin receptor subtype 7 (5-HTSynapse (New York, N.Y.) · 2018Article
- Evaluating Marine Cyanobacteria as a Source for CNS Receptor Ligands.Molecules (Basel, Switzerland) · 2018Article
- Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium.Journal of medicinal chemistry · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
contextMarine cyanobacteria offer a robust resource for natural products drug discovery due to the secondary metabolites they produce.
objectiveTo identify novel cyanobacterial compounds that exhibit CNS psychoactive effects. MATERIALS AND
methodsCyanobacteria were collected from Las Perlas Archipelago, Panama and subjected to dichloromethane/methanol extraction and fractionation by column chromatography before being screened for affinity against a panel of CNS targets. A 50:50 ethyl acetate:methanol fraction of one cyanobacterial extract (2064H) was subjected to HPLC and the major peak was isolated (2064H3). At a dose of 20 μg per animal, 2064H and 2064H3 were tested in mice using behavioral assays that included the forced swim, open field and formalin tests.
results2064H was shown to bind to the serotonin 2C (5-HT DISCUSSION AND
conclusionOverall, manipulating the 5-HT
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.