Trial reportRevista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo2016
Use of honey associated with Ananas comosus (Bromelin) in the treatment of acute irritative cough.
Trial report in Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Honey for acute cough in children.The Cochrane database of systematic reviews · 2018Pooled it
- Efficacy and safety of the syrup "KalobaTUSS®" as a treatment for cough in children: a randomized, double blind, placebo-controlled clinical trial.BMC pediatrics · 2021Trial
- Phytotherapeutic, Homeopathic Interventions and Bee Products for Pediatric Infections: A Scoping Review.Nutrients · 2025Article
- Current Uses of Bromelain in Children: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Geographical Origin Authentication-A Mandatory Step in the Efficient Involvement of Honey in Medical Treatment.Foods (Basel, Switzerland) · 2024Review
- High Retention and Purification of Bromelain Enzyme (Polymers · 2022Article
- Honeybee products for the treatment and recovery from viral respiratory infections including SARS-COV-2: A rapid systematic review.Integrative medicine research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the immediate improvement rate of irritative cough in patients treated with the combination of Ananas comosus extract and honey (Bromelin
methodsPragmatic, double-blind, randomized, parallel-group study with children aged between 2 and 15 years, with irritative cough for at least 24hours. The double-blind assessment of cough was through the number of observed coughing episodes and intensity score for a period of 10minutes of observation. The decrease of one point in the mean total score was considered as a therapeutic effect.
resultsThere was a reduction in coughing episodes in both groups, as well as in the cough score after 30minutes of drug or honey administration. The change in clinical score above two points, which could indicate marked improvement, occurred in five patients in the bromelin group and only in one in the placebo group, but without significant difference. There were no adverse events.
conclusionsThe immediate improvement rate of irritative cough was similar in patients treated with combination of Ananas comosus extract and honey (Bromelin
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Registered trials
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