ArticleScientific reports2016
Reduced cerebral blood flow and oxygen metabolism in extremely preterm neonates with low-grade germinal matrix- intraventricular hemorrhage.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 59 citations in OpenAlex.
- Noninvasive diffuse optical monitoring of cerebral blood flow and oxygenation responses to intermittent hypoxia in neonatal rats.Journal of biomedical optics · 2026Article
- Amplitude-integrated electroencephalography for early diagnosis and severity assessment of neonatal intracranial hemorrhage: a multicenter retrospective study.Italian journal of pediatrics · 2026Article
- Associations between postnatal cerebral oxygen availability and utilization in very to late preterm infants and neurodevelopmental outcome.Scientific reports · 2026Observational
- The impact of different types of brain injuries on cerebral perfusion in preterm infants: an arterial spin labeling : MRI study.Scientific reports · 2025Article
- Programmable scanning diffuse speckle contrast imaging of cerebral blood flow.Neurophotonics · 2025Article
- Diagnostic prediction of neonatal hyperbilirubinemia combined with germinal matrix-intraventricular hemorrhage based on cranial ultrasound hemodynamics: a retrospective case-control study.Frontiers in medicine · 2025Article
- Frequency-domain instrument with custom ASIC for dual-slope near-infrared spectroscopy.The Review of scientific instruments · 2024Article
- Cerebral baseline optical and hemodynamic properties in pediatric population: a large cohort time-domain near-infrared spectroscopy study.Neurophotonics · 2024Article
- Article
- Multi-wavelength multi-distance diffuse correlation spectroscopy system for assessment of premature infants' cerebral hemodynamics.Biomedical optics express · 2024Article
- Chassis-based fiber-coupled optical probe design for reproducible quantitative diffuse optical spectroscopy measurements.PloS one · 2024Article
- Ventilatory Support, Extubation, and Cerebral Perfusion Changes in Pre-Term Neonates: A Near Infrared Spectroscopy Study.Neurotrauma reports · 2024Article
- Cerebral near-infrared spectroscopy monitoring to predict periventricular-intraventricular haemorrhage and neurodevelopmental outcomes in preterm infants: a protocol for a systematic review and meta-analysis.BMJ paediatrics open · 2023Article
- Associations between neurological examination at term-equivalent age and cerebral hemodynamics and oxygen metabolism in infants born preterm.Frontiers in neuroscience · 2023Article
- Association of early cerebral oxygen saturation and brain injury in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Cerebral gray matter injuries in infants with intraventricular hemorrhage.Seminars in perinatology · 2022Review
- Association Analysis of the Cerebral Fractional Tissue Oxygen Extraction (cFTOE) and the Cerebral Oxygen Saturation (crSaOJournal of clinical medicine · 2022Article
- Magnetic resonance imaging metrics of oxygen extraction fraction: Contradictions or insight into pathophysiological mechanisms?American journal of hematology · 2022Article
- Article
- Assessing cerebral blood flow, oxygenation and cytochrome c oxidase stability in preterm infants during the first 3 days after birth.Scientific reports · 2022Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Low-grade germinal matrix-intraventricular hemorrhage (GM-IVH) is the most common complication in extremely premature neonates. The occurrence of GM-IVH is highly associated with hemodynamic instability in the premature brain, yet the long-term impact of low-grade GM-IVH on cerebral blood flow and neuronal health have not been fully investigated. We used an innovative combination of frequency-domain near infrared spectroscopy and diffuse correlation spectroscopy (FDNIRS-DCS) to measure cerebral oxygen saturation (SO2) and an index of cerebral blood flow (CBFi) at the infant's bedside and compute an index of cerebral oxygen metabolism (CMRO2i). We enrolled twenty extremely low gestational age (ELGA) neonates (seven with low-grade GM-IVH) and monitored them weekly until they reached full-term equivalent age. During their hospital stay, we observed consistently lower CBFi and CMRO2i in ELGA neonates with low-grade GM-IVH compared to neonates without hemorrhages. Furthermore, lower CBFi and CMRO2i in the former group persists even after the resolution of the hemorrhage. In contrast, SO2 does not differ between groups. Thus, CBFi and CMRO2i may have better sensitivity than SO2 in detecting GM-IVH-related effects on infant brain development. FDNIRS-DCS methods may have clinical benefit for monitoring the evolution of GM-IVH, evaluating treatment response, and potentially predicting neurodevelopmental outcome.
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