Evidence map›Paper›PMID 27181332›Full record

ArticleCellular & molecular immunology2018

BCR-ABL-specific CD4

Norihiro Ueda, Rong Zhang, Minako Tatsumi, Tian-Yi Liu, Shuichi Kitayama, Yutaka Yasui, Shiori Sugai, Tatsuaki Iwama, Satoru Senju, Seiji Okada and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Antigen Targets for the Development of Immunotherapies in Leukemia.International journal of molecular sciences · 2019
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Norihiro UedaDivision of Immunology, Aichi Cancer Center Research Institute, Nagoya 464-0021, Japan.
Rong ZhangDivision of Immunology, Aichi Cancer Center Research Institute, Nagoya 464-0021, Japan.
Minako TatsumiDivision of Immunology, Aichi Cancer Center Research Institute, Nagoya 464-0021, Japan.
Tian-Yi LiuDivision of Immunology, Aichi Cancer Center Research Institute, Nagoya 464-0021, Japan.
Shuichi KitayamaShin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
Yutaka YasuiShin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
Shiori SugaiDivision of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan.
Tatsuaki IwamaDivision of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan.
Satoru SenjuDepartment of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Seiji OkadaDivision of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto 860-0811, Japan.
Tetsuya NakatsuraDivision of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan.
Kiyotaka KuzushimaDivision of Immunology, Aichi Cancer Center Research Institute, Nagoya 464-0021, Japan.
Hitoshi KiyoiDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya 466-0065, Japan.
Tomoki NaoeNational Hospital Organization Nagoya Medical Center, Nagoya 460-0001, Japan.
Shin KanekoShin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
Yasushi UemuraDivision of Immunology, Aichi Cancer Center Research Institute, Nagoya 464-0021, Japan.
Aichi Cancer Center · JPChiba Cancer Center · JPKyoto University · JPKumamoto University · JPChinese PLA General Hospital · CNNagoya Medical Center · JPNagoya University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of tyrosine kinase inhibitor (TKI) therapy markedly improved the outcome of patients with chronic-phase chronic myeloid leukemia (CML). However, the poor prognosis of patients with advanced-phase CML and the lifelong dependency on TKIs are remaining challenges; therefore, an effective therapeutic has been sought. The BCR-ABL p210 fusion protein's junction region represents a leukemia-specific neoantigen and is thus an attractive target for antigen-specific T-cell immunotherapy. BCR-ABL p210 fusion-region-specific CD4

Indexed as

Amino Acid SequenceAnimalsCell DifferentiationCell ProliferationClone CellsCross-PrimingDendritic CellsEpitopesFusion Proteins, bcr-ablHLA-DR Serological SubtypesHumansInterferon-alphaInterleukin-12LeukemiaMiceMice, Inbred BALB CEpitopesFusion Proteins, bcr-ablHLA-DR9 antigenHLA-DR Serological SubtypesInterferon-alphaInterleukin-12PeptidesProtein Kinase InhibitorsReceptors, Antigen, T-Cell

Identifiers

PMID27181332
PMCPMC5827172
OpenAlexW2394873631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.