ArticleThe Analyst2016
Glycan heterogeneity on gold nanoparticles increases lectin discrimination capacity in label-free multiplexed bioassays.
Article in The Analyst, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Deciphering the Heterogeneity of Pulmonary Macrophages in Response to Fine Particles.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Glycopolymer-Functionalized Gold Nanoparticles for the Detection of Western Diamondback Rattlesnake (Biomacromolecules · 2025Article
- Monosaccharide coating modulate the intracellular trafficking of gold nanoparticles in dendritic cells.Materials today. Bio · 2024Article
- Sugar-decorated carbon dots: a novel tool for targeting immunomodulatory receptors.Nanoscale advances · 2022Article
- Isolipoic acid-linked gold nanoparticles bearing the thomsen friedenreich tumor-associated carbohydrate antigen: Stability andFrontiers in chemistry · 2022Article
- Review
- The polymeric glyco-linker controls the signal outputs for plasmonic gold nanorod biosensors due to biocorona formation.Nanoscale · 2021Article
- Green chemistry and coronavirus.Sustainable chemistry and pharmacy · 2021Review
- Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands.Chemical science · 2020Article
- Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties.Materials today. Bio · 2020Article
- Glycan Nanobiosensors.Nanomaterials (Basel, Switzerland) · 2020Review
- Recent Advances in the Application of Glycan-Modified Self-Assembled Monolayers.Advances in chemistry research · 2020Article
- Polymer-Stabilized Sialylated Nanoparticles: Synthesis, Optimization, and Differential Binding to Influenza Hemagglutinins.Biomacromolecules · 2020Article
- An array consisting of glycosylated quantum dots conjugated to MoSMikrochimica acta · 2018Article
- Triggerable Multivalent Glyconanoparticles for Probing Carbohydrate-Carbohydrate Interactions.ACS macro letters · 2018Article
- Multivalent Antimicrobial Polymer Nanoparticles Target Mycobacteria and Gram-Negative Bacteria by Distinct Mechanisms.Biomacromolecules · 2018Article
- Immobilization of glycans on solid surfaces for application in glycomics.Journal of carbohydrate chemistry · 2018Article
- Presenting Precision Glycomacromolecules on Gold Nanoparticles for Increased Lectin Binding.Polymers · 2017Article
- Comparison of RAFT derived Poly(vinylpyrolidone) verses Poly(oligoethyleneglycol methacrylate) for the Stabilization of Glycosylated Gold Nanoparticles.Journal of polymer science. Part A, Polymer chemistry · 2017Article
- Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition.Nanoscale horizons · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The development of new analytical tools as point-of-care biosensors is crucial to combat the spread of infectious diseases, especially in the context of drug-resistant organisms, or to detect biological warfare agents. Glycan/lectin interactions drive a wide range of recognition and signal transduction processes within nature and are often the first site of adhesion/recognition during infection making them appealing targets for biosensors. Glycosylated gold nanoparticles have been developed that change colour from red to blue upon interaction with carbohydrate-binding proteins and may find use as biosensors, but are limited by the inherent promiscuity of some of these interactions. Here we mimic the natural heterogeneity of cell-surface glycans by displaying mixed monolayers of glycans on the surface of gold nanoparticles. These are then used in a multiplexed, label-free bioassay to create 'barcodes' which describe the lectin based on its binding profile. The increased information content encoded by using complex mixtures of a few sugars, rather than increased numbers of different sugars makes this approach both scalable and accessible. These nanoparticles show increased lectin identification power at a range of lectin concentrations, relative to single-channel sensors. It was also found that some information about the concentration of the lectins can be extracted, all from just a simple colour change, taking this technology closer to being a realistic biosensor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.