Evidence map›Paper›PMID 27181159›Full record

ArticleScandinavian journal of gastroenterology2016

A genetic variant in proximity to the gene LYPLAL1 is associated with lower hunger feelings and increased weight loss following Roux-en-Y gastric bypass surgery.

Marcus Bandstein, Jessica Mwinyi, Barbara Ernst, Martin Thurnheer, Bernd Schultes, Helgi B Schiöth

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Article in Scandinavian journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marcus Bandsteina Department of Neuroscience, Functional Pharmacology , Uppsala University , Uppsala , Sweden ;
Jessica Mwinyia Department of Neuroscience, Functional Pharmacology , Uppsala University , Uppsala , Sweden ;
Barbara Ernstb Interdisciplinary Obesity Center , eSwiss Medical & Surgical Center , St. Gallen , Switzerland.
Martin Thurnheerb Interdisciplinary Obesity Center , eSwiss Medical & Surgical Center , St. Gallen , Switzerland.
Bernd Schultesb Interdisciplinary Obesity Center , eSwiss Medical & Surgical Center , St. Gallen , Switzerland.
Helgi B Schiötha Department of Neuroscience, Functional Pharmacology , Uppsala University , Uppsala , Sweden ;

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveBariatric surgery is the most efficient treatment of severe obesity. We investigated to what extent BMI- or waist-hip ratio (WHR)-related genetic variants are associated with excess BMI loss (EBMIL) two years after Roux-en-Y gastric bypass (RYGB) surgery, and elucidated the affected biological pathways.

methodsTwo-hundred fifty-one obese patients (age: 43 ± 10.7, preoperative BMI: 45.1 ± 6.1 kg/m(2), 186 women) underwent RYGB surgery and were followed up after two years with regard to BMI. Patients were genotyped for 32 single-nucleotide polymorphisms (SNPs) that were investigated with regard to their impact on response to RYGB and preoperatively measured Three Factor Eating Questionnaire (TFEQ) scores.

resultsHomozygous T carriers of the SNP rs4846567 in proximity to the Lysophospholipase-like 1 (LYPLAL1) gene showed a 7% higher EBMIL compared to wild-type and heterozygous carriers (p = 0.031). TT-allele carriers showed furthermore lower scores for Hunger (74%, p < 0.001), lower Disinhibition (53%, p < 0.001), and higher Cognitive restraint (21%, p = 0.017) than GG/GT carriers in the TFEQ. Patients within the lowest quartile of Hunger scores had a 32% greater EBMIL compared to patients in the highest quartile (p < 0.001).

conclusionThe LYPLAL1 genotype is associated with differences in eating behavior and loss of extensive body weight following RYGB surgery. Genotyping and the use of eating behavior-related questionnaires may help to estimate the RYGB-associated therapy success.

Indexed as

Gastric BypassAdultFeeding BehaviorFemaleGenotypeHumansHungerLinear ModelsLysophospholipaseMaleMiddle AgedObesity, MorbidPolymorphism, Single NucleotideSurveys and QuestionnairesSwitzerlandWeight LossLYPLAL1 protein, humanLysophospholipaseLYPLAL1rs4846567RYGBsingle nucleotide polymorphismThree Factor Eating Questionnaire

Identifiers

PMID27181159
PMCPMC4926774

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.